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Pharm Test 3 > Gout > Flashcards

Gout Flashcards

1
Q

Gout

a. allopurinol is effective in acute attacks

A

A. False. Allopurinol is only administered at least 4 weeks after an attack

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2
Q

Gout

b. probenicid inhibits the reabsorption of uric acid in the kidneys

A

B. True. Prevents the re-absorp5on of UA from the kidney at the PCT

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3
Q

Gout

c. aspirin is used to treat pain and inflammation during an acute attack

A

C. False. Aspirin can exacerbate symptoms

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4
Q

Gout

d. urine is alkalinised with probenecid treatment

A

D. False. Alkalinisation is advised. Uric acid excretion will acidify urine.

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5
Q

Gout

e. corticosteroids are contraindicated during an acute attack

A

E. False, corticosteroids are advised. Aspirin is contraindicated

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6
Q

Drugs used in the treatment of Gout

a. aspirin reduces serum uric acid levels in patients suffering with an acute attack of gouty arthritis

A

A. False. Aspirin should only be used if there are no other choices. At high doses, aspirin as a uricosuric effect

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7
Q

Drugs used in the treatment of Gout

b. allopurinol inhibits the migration of pro-inflammatory cytokines

A

B. False, Allopurinol blocks uric acid formation

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8
Q

Drugs used in the treatment of Gout

c. Concomitant use of probenecid and penicillin increases the plasma concentration of penicillin

A

C. True. Decreases the secretion of other weak acids e.g. Penicillin.

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9
Q

Drugs used in the treatment of Gout

d. colchicine is used in the treatment of an acute attack of gouty arthritis

A

D. True.

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10
Q

Drugs used in the treatment of Gout

e. colchicine is a xanthine oxidase inhibitor

A

E. False. Colchine:

  • Inhibits phagocytosis
  • Arrests cell division in G1 by interfering with microtubule and spindle formation (similar MOA to vinca alkaloids)
  • May alter neutrophil motility
  • Decreases the crystal-induced secretion of chemotactic factors and superoxide anions by activated neutrophils
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11
Q

In the treatment of rheumatoid arthritis and gout

a. methotrexate inhibits the action of tumour necrosis factor

A

A. False. Decreases antibody formation to TNF

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12
Q

In the treatment of rheumatoid arthritis and gout

b. leflunomide is contraindicated prior to falling pregnant

A

B. True. Needs to be cleared out the system for 2 years

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13
Q

In the treatment of rheumatoid arthritis and gout

c. infliximab decreases circulating tumour necrosis factor

A

C. True. Binds to circulating and bound TNF

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14
Q

In the treatment of rheumatoid arthritis and gout

d. colchicine is used to treat rheumatoid arthritis

A

D. False, colchine is used to treat gout

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15
Q

In the treatment of rheumatoid arthritis and gout

e. aspirin is used as an analgesic in gout

A

E. False.

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16
Q

Rheumatoid Arthritis and Gout

a. celecoxib is used to manage pain in arthritis

A

A. True. NSAIDs are used to manage pain

17
Q

Rheumatoid Arthritis and Gout

b. sulfasalazine increases uric acid secretion in gout

A

B. False. Sulfasalazine is a DMARD used in RA

18
Q

Rheumatoid Arthritis and Gout

c. methotrexate inhibits DNA synthesis in immune cells

A

C. False.

19
Q

Rheumatoid Arthritis and Gout

d. probenecid prevents the destruction of joints in rheumatoid arthritis

A

D. False

20
Q

Rheumatoid Arthritis and Gout

e. allopurinol inhibits xanthine oxidase

A

E. True

21
Q

In the treatment of gout, colchicine causes diarrhoea

A

True

22
Q

allopurinol is effective in an acute gouty attack

A

False. Only administer after acute attack has settled. >3 weeks. Acute gout attack treated with NSAIDS

23
Q

probenecid inhibits the reabsorption of uric acid in the kidneys

A

True

24
Q

a. colchicine causes diarrhoea

A

True

25
Q

b. probenecid inhibits phagocytosis

A

False, Prevents the re-absorp5on of UA from the kidney at the PCT

26
Q

c. colchicine is a xanthine oxidase

inhibitor

A

False, Inhibits phagocytosis, Arrests cell division in G1 by interfering with microtubule and spindle formation (similar MOA to vinca alkaloids), May alter neutrophil motility, Decreases the crystal-induced secretion of chemotactic factors and superoxide anions by ac5vated neutrophils

27
Q

d. low dose aspirin is used in the

management of an acute attack

A

False, CI

28
Q

e. colchicine is preferred to allopurinol

in an acute attack of gouty arthritis

A

True

Pharm Test 3 (6 decks)

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