Antivirals

Question 1

The antiviral agent is correctly paired with its use

a. oseltamivir – influenza

Answer 1

a. True, for influenza A and B

Question 2

The antiviral agent is correctly paired with its use

b. acyclovir – Herpes simplex infections

Answer 2

b. True, treatment of HSV (I & II), varicella zoster virus, prophylaxis of recurrent episodes (>6/year) of herpes genitalis

Question 3

The antiviral agent is correctly paired with its use

c. enfuvirtide – prevention of mother to child transmission in HIV

Answer 3

c. False, ENF is a fusion inhibitor. Give TDF + FTC + EFV (2 x NRTI and NNRTI)

Question 4

The antiviral agent is correctly paired with its use

d. lopinavir – resistant Herpes simplex infections

Answer 4

d. False, PI for HIV

Question 5

The antiviral agent is correctly paired with its use

e. lamivudine – HIV prophylaxis

Answer 5

e. True, PrEP is either tenofovir/ entricitabine or tenofovir/ lamivudine

Question 6

Acyclovir

a. is an acyclic adenosine analogue

Answer 6

a. False, guanosine analogue

Question 7

Acyclovir

b. is more active against CMV than HSV

Answer 7

b. False, primarily indicated for HSVS

Question 8

Acyclovir

c. inhibits viral DNA synthesis

Answer 8

c. True, DNA polymerase inhibitor

Question 9

Acyclovir

d. causes crystal nephropathy

Answer 9

d. True

Question 10

Acyclovir

e. is used in the last trimester of pregnancy to prevent congenital herpes

Answer 10

e. True, acyclovir treatment beginning at 36 weeks’ gestation for women who have recurrent genital HSV infection in pregnancy reduces the incidence of caesarean deliveries and viral transmission.

Question 11

Antiviral agents: acyclovir

a. has activity against HIV

Answer 11

a. False. Indicated for treatment of HSV (I & II), varicella zoster virus, prophylaxis of recurrent episodes (>6/year) of herpes genitalis

Question 12

Antiviral agents: acyclovir

b. is effective against influenza infections

Answer 12

b. False.

Question 13

Antiviral agents: acyclovir

c. is an acyclic guanosine analogue

Answer 13

c. True

Question 14

Antiviral agents: acyclovir

d. causes crystal nephropathy as an adverse effect

Answer 14

d. True

Question 15

Antiviral agents: acyclovir

e. crosses the blood brain barrier

Answer 15

e. True, Acyclovir crosses the blood-brain barrier, a desirable quality for the treatment of herpes encephalitis, neonatal herpes simplex virus infections, and, possibly, multiple sclerosis

Question 16

Antiviral agents: oseltamivir

a. inhibits nucleic acid synthesis in the influenza virus

Answer 16

a. False. Inhibits neuraminidase enzyme, preventing the spread of virus

Question 17

Antiviral agents: oseltamivir

b. decreases the total duration of symptoms of influenza A infections

Answer 17

b. True

Question 18

Antiviral agents: oseltamivir

c. is effective against influenza B virus infections

Answer 18

c. True, A and B

Question 19

Antiviral agents: oseltamivir

d. has activity against hepatitis B

Answer 19

d. False.

Question 20

Antiviral agents: oseltamivir

e. is used in the treatment of CMV infections

Answer 20

e. False, is used to treat influenza A and B

Question 21

The clinical uses of acyclovir are as follows:

a. HIV post-exposure prophylaxis

Answer 21

False

Question 22

The clinical uses of acyclovir are as follows:

b. Herpes simplex infections

Answer 22

True

Question 23

The clinical uses of acyclovir are as follows:

c. acute Varicella zoster infections in adults

Answer 23

True

Question 24

The clinical uses of acyclovir are as follows:

d. hepatitis B virus infections

Answer 24

False

Question 25

The clinical uses of acyclovir are as follows:

e. influenza infections

Answer 25

False