GOUT

Question 1

DEFINE GOUT (3 disturbances)

Answer 1

DISTURBANCE
1-purine metabolism
2-urine acc.
3-dep. of Na urates in tissues

Question 2

Cause

Answer 2

1-Primary type (90%) hereditary inborn error of purine metabolism———over prod. Of uric acid
2-Secondary gout (10%) due to other diseases
.myeloproflirative disorder
.renal diseases
.Drugs impairs uric acid excretion

Question 3

Trophi

Answer 3

Pathgnomonic lesion of gout

Question 4

Examples

Answer 4

1-arthritis
2-nephropathy
3-skin trophi

Question 5

Comp. Of trophus

Answer 5

Uric acid urate crystals
Granulomatous reaction ( macrophage, lymphocytes,fibroblast, foreign gaint cells )