GORD and PUD Flashcards

1
Q

Symptoms of Gerd

A
Heartburn 
Acid reflex 
oesophagitis
Halitosis 
Bloating and belching
Nausea and/or vomiting
Pain when swallowing (odynophagia) and/or difficulty swallowing (dysphagia)
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2
Q

Risk factors of Gerd

A
Obesity
Hernia
pregnancy 
Connective tissue disorders such as scleroderma 
Delayed stomach emptying
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3
Q

Two main types of hiatus hernia

Which has a risk of strangulation and what does this present as

A

Sliding- entire stomach moves upwards

Rolling - out pouching of stomach (possibility of strangulation)
–>Pain, unable to swallow because of gastric obstruction and feeling very bloated

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4
Q

Complications of GORD and symptoms

A

Oesophageal ulcers- bleeding, pain, odynophagia

Oesophageal stricture- dysphagia, odynophagia

Barretts oesophagus- normal stratified squamous to simple columnar

Oesophageal cancer- dysphagia, weight loss, persistent indigestion, hoarseness, persistent cough, haemoptysis, vomiting

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5
Q

Investigations to confirm gord

A

Refer if :

  • Unsure of good diagnosis
  • Symptoms are persistent, severe or unusual
  • Not controlled by prescribed medication
  • May benefit from surgery
  • Signs of a potentially more severe condition, such as difficulty swallowing or unexplained weight loss
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6
Q

When to refer tor endoscopy same day

A

Presenting with dyspepsia with significant acute GI bleeding, refer on same day

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7
Q

Specialist investigations for GORD

A

oesophageal manometry and ambulatory 24h oesophageal pH monitoring (to quantify reflux and asses relationship between reflux episodes and person’s symptoms

Barium swallow meal to help exclude structural disorders such as hiatus hernia or motility disorders such as achalasia

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8
Q

Interventions for GORD

A

Offer full dose PPI for 8 weeks. Offer a full-dose PPI long term as maintenance treatment for people with severe oesophagitis

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9
Q

What are peptic ulcers

A

Defects in the gastric or duodenal mucosa that extend through the muscular mucosa

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10
Q

Duodenal ulcer symptom

A

May improve with food (delay gastric emptying)

May present with bleeding (posterior ulcer) or perforation (anterior)

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11
Q

Gastric ulcer symptom

A

May be more painful immediately after food

May present with small bleed (iron deficiency anaemia) or major haemorrhage (haematemesis)

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12
Q

causes of PUD

A

H.pylori

Long term used of NSAIDs, or high dose corticosteroids

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13
Q

What makes PUD worse

A

Stress
spicy food
Alcohol
Smoking

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14
Q

common symptoms of PUD

A
burning stomach pain
Feeling of fullness, bloating or belching
Fatty food intolerance
Heartburn
Nausea
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15
Q

Severe signs of ulcers

A
Vomiting or vomiting blood (red or black)
Dark blood in stools or stools that are black or tarry
trouble breathing
Feeling faint
N&V
Unexplained weight loss
Appetite changes 
Severe abdo pain (perforation)
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16
Q

How does stoking affect GI tract

A

Disrupts mucus renewal (which normally protects lining of stomach)
Disrupts proliferation of mucosal cells
Causes issues with blood flow, decrease immunity and protection imbalance

17
Q

How do NSAIDs affect GI tract

A

Inhibit arachidonic acid pathway which inhibits COX1+2 pathway. Decreased prostaglandin production and therefore decrease platelet aggregation, vasodilation, inflammation response and increase gastric secretions

18
Q

What gram is h.pylori

A

Gram -ve

19
Q

How does h.pylori affect stomach

A

Produce urease enzyme that will hydrolyse urea –>ammonia

Ammonia neutralises gastric acid and damages mucosal wall

Those with peptic ulcers are commonly found to have H.pylori infections

20
Q

Risks of H.pylori

A

Duodenal ulcer
Chronic gastritis
Gastric cancer
gastric ulcer

21
Q

Testing for h.pylori

A

carbon 13 urea breath test or a stool antigen test

Lab based serology

22
Q

When should urgent referrals for endoscopy be done

A
With dysphagia or 
Aged 55 and over with weight loss and any of the following:
-Upper abdo pain
-Reflux 
-Dyspepsia
23
Q

When to repeat endoscopy

A

ppl with gastric ulcer and pylori repeat endoscopy 6-8 weeks after beginning treatment, depending on size of lesion
Offer people with peptic ulcers and pylori retesting for h.pylori 6-8 weeks after beginning treatme, depending on the size of the lesion
Perform -retesting for h.pylori using a carbon13 urea breath test. Don’t use stool anitigen test