GORD

Question 1

What are the 4 drugs given to treat peptic ulcers?

Answer 1

NSAIDS
Paracetamol
PPI-omeprazole and lansoprazole
Histamine 2 receptor antagonists- ranitidine

Question 2

What is the action mechanism of NSAIDS?

Answer 2

Inhibit cyclo-oxygenase which is the rate limiting step for production of prostaglandin
Prostaglandin bind to receptors that cause nociceptors mediators to cause pain

Question 3

What are the side effects of NSAIDS?

Answer 3

Gastric irritation and ulceration
Skin rash
Hypertension
Renal failure after long term use

Question 4

Why do prostaglandin inhibition increase chances of ulcers?

Answer 4

Protect from acid by increasing bicarbonate release and mucus production in gastric mucosal cells

Question 5

What is the action mechanism of PPI?

Answer 5

Inhibit H+/K+ATPase pump in gastric parietal cells
Inhibit gastric secretion by 90%

Question 6

What are the side effects of PPI?

Answer 6

Diarrhoea
Headache
Bloating
Abdo pain

Question 7

What is the action mechanism of h2 receptor antagonists?

Answer 7

Competitive antagonists of receptors
No histamine released from enterochromaffin like cells
Inhibit gastric acid secretion by 60%

Question 8

Why would a patient with osteoporosis be given h2 antagonist rather than PPI?

Answer 8

PPI decreases amount of calcium digested (needed for bones)