CKD

Question 1

What is the action mechanism of statins?

Answer 1

Competitively inhibit HMG-Coa reductase
This increases the amount of LDL receptors (which clear LDL) and therefore increased hepatic uptake of LDL cholesterol from the blood

Question 2

What is the side effect of statins?

Answer 2

Muscle toxicity
GI problems

Question 3

What is the action mechanism of aspirin?

Answer 3

Inactivates COX = no prostaglandins
Reduced A2 thromboxane = platelets cannot aggregate

Question 4

What is the side effects of aspirin?
What should be given to patients with PMH of peptic ulcers?

Answer 4

Haemorrhages
If PMH of peptic ulcers- give PPI

Question 5

What is the action mechanism of trimethropin?
Why can we not use GFR levels in people taking trimethropin?

Answer 5

Decreases amount of protein made by competing for dihydrofolate reductase = tetrahydrofolic acid can’t be made which is needed for protein production

Inhibits secretion of creatinine

Question 6

What is the action mechanism of gentamicin?

Answer 6

Binds to the bacterial 30s ribosomal subunit = mRNA translation disruption = dysfunctional proteins made

Question 7

What is given for patients with proteinurea?

Answer 7

ACEi- relax efférent artériole
SGLT-2
Salt restriction