Goodpasture's syndrome

Question 1

what is goodpasture’s syndrome?

Answer 1

Nephritic syndrome

Question 2

what are the key presentations of goodpasture’s syndrome?

Answer 2

malaise, unintentional weight loss, arthralgias, fever, shortness of breath, cough, haemoptysis

Question 3

what are the first line and gold standard investigations for goodpasture’s syndrome?

Answer 3

Anti Glomerular basement membrane antibodies
Kidney biopsy - development of crescent shape as glomerular basement membrane breaks, antibodies bind to collagen of basement membrane

Question 4

how is goodpasture’s syndrome managed?

Answer 4

Plasmapheresis
Immunosuppression
Pulse therapy - corticosteroids