Good Luck Flashcards
keratins
-epithelium
- terminate in desmosomes and site of cell-cell adhesion
vimentin
- mesenchyme
- attach nucleus to plasma membrane
Desmin
- muscle cell
- framework for attachment of contractile proteins
neurofilaments
- neurons
- internal support and maintaining gel state of cytoplasm
microtubules
- role in cell shape maintenance, development, and intracellular transport
- conspicuous in dividing cells
lysosomes
- intracellular digestion
- in cells with phagocytic activity (macrophages)
Golgi
- completes modification of proteins, packages and directs to destination
- proteins released in vesicles from trans face
ribosomes
- basophilic b/c phosphate groups
- stains with hematoxylin
- decode mRNA message for translation into protein
peroxisomes
- oxidize organic materials by transferring hydrogen atoms to molecular oxygen
- results in toxic hydrogen peroxide removed by catalase
proteasome
- complexes that digest proteins targeted for destruction by ubiquination
- moves excess proteins or incorrectly folded proteins
apoptosis
- programmed cell death
- requires energy
necrosis
- accidental cell death
- cells swell and release intracellular components
receptor mediated endocytosis
- receptors bind to ligands
- creates vesicles that lose their clathrin coat to fuse w/ endosomes
endosomes
intracellular sorting organelles containing ATP proton pumps
desmosomes
mediate cell-cell contact and strong adhesion
glycocalix
- a network of polysaccharides that project from cellular surfaces of bacteria
- “sugar coat”
- stabilizes membrane, cell recognition
- adhesion
chaperone proteins
- assisting protein folding under stress conditions
GFAP
- found in astrocytes
- glial cell (connective tissue)
cell web
located at periphery of cell (ectoplasm)
- establishes and maintains shape of cell
secondary active transport
dec intake of NA+ and glucose
anterior transport
COP-II cys to trans to plasma membrane
retrograde transport
COP-I protein transport
P53
- helps prevent the development of tumors
- regulating DNA repair and cell division
irreversible cell injury
- mitochondrial swelling
- loss of plasma membrane integrity
- Lysosome swell and auto lyseauto digestion of cell
- ca+ influx
- Leakage of CK(cytokinase) and LDH(lactate dehydrogenase ) into serum
competitive inhibition
- role in the detoxification of xenobiotics, cellular metabolism and homeostasis.
- drug detox
cytochrome P450
first pass effect- liver- drug detox
MTOR Pathway
signal in ridding of ribosomes because they’re not making protein in starvation
glucose sparing effect
a switch by most tissues from utilizing glucose as an energy source to utilizing fatty acids.
reperfusion injury
exacerbation of cellular dysfunction and death, following restoration of blood flow to previously ischemic tissues.
ubiquitin pathway
misfolded protein
BAX
pro-apoptic gene
if greater than BCL2=cell death
cytochrome C
- fn in apoptosis
- in mitochondria
- ↑Ca2+, lose H+
Glut-2 transporter
transports glucose into the cell
downregulation
receptors become less sensitive
SNARE
-Help guide vesicle to correct target membrane
- v-SNARE: on vesicle
t-SNARE: on target membrane
peripheral proteins
- loosely associated, weak (non-covalent), removable with mild treatment
- not embedded
integral proteins
- strongly associated, strong hydrophobic, harsh treatments to remove
- Penetrate hydrophobic core and span membrane(transmembrane proteins)
lipid rafts
localized regions of membrane lipids in association with specific proteins (neurological disease)
proto-oncogenes
genes that promote growth (gas pedal on a car) via growth factor
sequence of events proto-oncogenes
Growth factor binds to cell membrane R -> signal transducer* -> 2nd messenger system* which carries signal -> nucleus -> growth genes* -> growth induction
G1-S checkpoint
delays the start of a new cycle to either fix or kill damaged cell via apoptosis
S phase checkpoint
delays DNA synthesis
S-M (G2) checkpoint
delays mitosis (e.g. spindle assembly checkpoint delays anaphase until chromosomes are aligned proper
LLPS
how the cell organizes before