Gonadotropins and related drugs Flashcards
Gonadotropins (5 drugs)
Menotropins Chorionic gonadotropin Choriogonadotropin alpha Follitropin alfa + beta Lutropin alfa
Gonadotropins - indications
Infertility (men and women)
Hypogonadism (men)
Acites, hydrothorax, hypovolemia and shock is characteristic for a syndrome caused by which group of drugs?
Ovarian hyperstimulation syndrome, an adverse effect of gonadotropins
Gonadotropins- adverse effects
Ovarian hyperstimulation syndrome
Multiple pregnancies
Depression
Which gonadotropin is used for cryptorchidism?
Chorionic gonadotropin
GnRH agonists (5 drugs)
Histrelin Goserelin Leuprolide Nafarelin Triptorelin
GnRH agonist administered by 12 month active subcutaneous implant and its indications
Histrelin - Used only for central precocious puberty
GnRH agonists - contraindications
Pregnancy
Breast feeding
GnRH agonists - adverse effects
Symptoms of menopause
GnRH agonists - mechanism of action
Binds to G protein-coupled receptors (GnRH-receptors).
Pulsatile adm: stimulate release of FSH and LH from pituitary.
Continuous adm: Down-regulation of GnRH-receptors and decreased FSH + LH secretion.
GnRH agonist administered by nasal spray and its indication
Nafarelin - used for endometriosis and central precocious puberty
Goserelin and leuprolide - indications
Advanced prostate cancer
Advanced breast cancer
Endometriosis
What is important at the start of goserelin and leuprolide treatment for prostate cancer?
Testosterone antagonist is co-administered in the beginning
GnRH antagonists (3 drugs)
Ganirelix
Cetrorelix
Degarelix
GnRH antagonists - MOA
Competitive inhibition of FSH and LH secretion
