Glycolysis Flashcards
is there any hormonal control of TCA
no
it has to run all time irrespective of fed and unfed state
which is the major control enz of tca
isocitrate dehydrogenase
atp adp nadh
what is the defect in leigh syndrome
oxidative phosphorylation
enz seen in mi
LDH( 1>2)
creatinine kinase-MB
troponin I and T(appear ib 3-6 hrs-peak at 16 hrs-remain elevated for a week)
inhibitors of etc CoQ complex3 complex4 Fo
dixorubicin
antimycin
CO,cyanide
oligomycin
what is the effect of uncouplers on
ATP
O2consumtion
oxidation on NADPH
dec inc inc H+ gradient is disturbed- no atp since less atp faster the cucle and more the O2 consumption
where is brown adipose tissue present
role
newborn .neck .kidney .scapula breastplate role:to maintain basal temperature
natural UCP
thermogenin in brown adipose tissue
UCP egs
DNP
high dose salicylates(eg aspirin in a dose for RA)
mutation in mtDNA effect which process and tissue mainly
OP
highly aerobic tissues are effected like brain and muscle
maternal inheritance
name 3 mitochondrial ds
- leber hereditary optic neuropathy
- myclonic epilepsy with ragged red muscle fibres
- MELAS
MELAS stands for
mitochondrial encephalomyopathy
lactic acidosis
stroje like episodes
