Glutamate Receptors in Learning and Memory Flashcards
What are some features of the AMPA receptor?
conducts Na
blocked by CNQX
activated by AMPA, glutamate
mediates fast, excitatory synaptic transmission
What are some features of the NMDA receptor?
conducts Ca and is blocked by Mg
Glycine or D-serine is co-agonist
blocked by APV
implicated in LTP and consequently learning and memory
What does activation of NMDA receptors require?
binding of glutamate and co-agonist glycine and co-expression of AMPA receptors as require depolarisation to remove Mg block
What is used to block the NMDA receptor?
AP5
How do we know that AP5 did not produce sensory and locomotor deficits?
placing a beacon on the platform allowed the mouse to find it through sight
How is long-term memory categorised?
procedural
declarative
How is declarative learning categorised?
semantic
episodic
How has paired-associate learning been replicated in animal?
foods are put in locations in an arena, start in different places so they have to find different ways to the food, given a taste smell of one flavour and have to go to a matched location
What should animals do in the paired associate learning?
learn a strategy
avoid novel locations
persist
What happens to paired associate learning when the drugs are administered before learning?
Both AP5 and CNQX experience deficits in learning and memory
What happens to paired associate learning when the drugs are added after learning but before recall?
AP5 shows normal recall
CNQX shows deficits in recall
What does CNQX block?
fast synaptic transmission
What does AP5 block?
long term potentiation
What is required for recall?
fast synaptic transmission - AMPA
What is required for learning?
fast synaptic transmission and long term potentiation
