GABA receptor pharmacology Flashcards
1
Q
What is the GABA transporter?
A
GAT 1-3
2
Q
What is the VGAT?
A
vesicular GABA Amino acid transporter
3
Q
What are the effects of drugs acting on GABA?
A
anxiolytic, sedative, analgesic, amnestic, hypnotic, anaesthetic, anticonvulsant
4
Q
What are PAMs of GABA?
A
diazepam
5
Q
What is an Antagonist of GABA?
A
flumazenil
6
Q
WHat is a NAM of GABA?
A
b-carbolin
7
Q
What effects are caused by a1?
A
sedative, not addictive
8
Q
What effects are caused by a2?
A
anxiolytic, analgesic, develops tolerance
9
Q
What effects are caused by a5?
A
KO causes improved performance
10
Q
Where are a5 found?
A
hippocampal CA1 neurons - tonic current
11
Q
What effects are lost with a5 KO?
A
sedative, general anaesthetic and cognitive impairment
12
Q
How can you assay for recombinant GABAaRs?
A
displacement of 3H flunitrazepam
Whole cell clamp
