Endocannabanoids Flashcards
What are some localisations for ECB?
Hippocampus
Basal Ganglia
Cerebellum
What is the difference between CB1 and CB2?
CB1 has a much longer EC and IC terminal
What does CB1 modulate conducation of?
Ca or K
What is the action of CB1?
suppresses neuronal excitability, NT realease
NO production
Na Channel conduction
On what kind of neurons can CB1 be found?
Gabaergic
What are the two known stimulators of CB1?
Anandamide
2-AG
What breaks down Anandamide
FAAH
What breaks down 2-AG
MGL
What is a DSI?
depolarisation induced suppression of inhibition
What is a DSE?
depolarisation induce suppression of excitation
What is retrograde transmission?
endocannabanoid released back to the presynaptic receptor to inhibit Ca influx and the release of GABA
What are the chronic effects of ECB use?
respiratory effects cardiovasular arrhythmia immune comprimised reproduction compromised amotivational impaired thinking and reasoning increased tolerance and addiction
What are the acute effects?
impaired STM and learning
anxiety, fear
analgesia
increased apetite
What happens to food intake and body weight gain?
reduced in rats when antagonised
What helps synthesis 2-AG?
DAG
