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Neuroscience > Glutamate Receptors > Flashcards

Glutamate Receptors Flashcards

1
Q

What are the ionotropic glutamate receptors?

A

NMDA, AMPA and Kainate

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2
Q

What ions are NMDA receptors permeable to?

A

Sodium, Potassium, Calcium

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3
Q

How many subunits does the NMDA receptor have?

A

4

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4
Q

What is the subunit composition of an NMDA receptor?

A

Made up of any from GluN1-3
Always at least two GluN1 subunits
Usually GluN2A and GluN2B subunits

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5
Q

Ligands of the NMDA receptor

A

NMDA, Aspartate, Glutamate

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6
Q

Modulators of the NMDA receptor

A

Glycine, D-serine, Polyamines (such as magnesium and zinc)

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7
Q

Where can NMDA receptors be located?

A

Presynaptically
Postsynaptically
On glial cells

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8
Q

What are the functions of the NMDA receptor?

A

Slower, longer-lasting EPSPs
Synaptic plasticity - LTP and LTD
Excitotoxicity

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9
Q

What ions are AMPA receptors permeable to?

A

Sodium and potassium

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10
Q

How many subunits does the AMPA receptor have?

A

4

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11
Q

What are the 3 requirements for NMDA receptor activation?

A

Glutamate/Aspartate/NMDA binding
Co activation by glycine or D-serine
Depolarisation of neuron to remove the magnesium block

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12
Q

Where can AMPA receptors be located?

A

Postsynaptically

On glial cells

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13
Q

What are the functions of the AMPA receptor?

A

Fast EPSPs

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14
Q

What ions are Kainate receptors permeable to?

A

Sodium and potassium

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15
Q

How many subunits does the Kainate receptor have?

A

4

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16
Q

What is the subunit composition of an AMPA receptor?

A

Made of up any from GluA1-4 subunits

Always has GluA2 subunit

17
Q

What is the subunit composition of a Kainate receptor?

A

Made up of any from GluK1-5 subunits

18
Q

Where can Kainate receptors be located?

A

Presynaptically
Postsynaptically
(Limited distribution)

19
Q

What are the functions of the Kainate receptor?

A

Fast EPSPs

Presynaptic inhibition

20
Q

What are the metabotropic glutamate receptors?

A

mGlu1-8

21
Q

What are the groups of metabotropic glutamate receptors and which receptors does each group contain?

A

Group 1: mGlu 1, 5
Group 2: mGlu 2, 3
Group 3: mGlu 4, 6-8

22
Q

What G-protein are Group 1 mGlu receptors coupled to?

A

Gq

23
Q

Where are Group 1 mGlu receptors located?

A

Postsyanptically

On glial cells

24
Q

Where are Group 2 mGlu receptors located?

A

Presynaptically

25
Q

Where are Group 3 mGlu receptors located?

A

Presynaptically

26
Q

What G-protein are Group 2 and Group 3 mGlu receptors coupled to?

A

Gi/o

27
Q

What is the function of Group 1 mGlu receptors?

A

Slow excitatory neurotransmission

Increases postsynaptic intracellular calcium

28
Q

What is the function of Group 2 and Group 3 mGlu receptors?

A

Slow inhibitory neurotransmission
Open presynaptic potassium channels
Reduce presynaptic intracellular calcium
Prevent neurotransmitter release

Neuroscience (12 decks)

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