GLUT4 journal

Question 1

Which fibers have a greater GLUT4 expression

Answer 1

Type I

Question 2

Knocking out GLUT4 causes

Answer 2

Dysregulated glucose metabolism and impaired insulin action

Question 3

Exercise training increases

Answer 3

GLUT 4 expression

Question 4

During basal conditions where is GLUT4 located

Answer 4

cytosol

Question 5

What stimulates the translocation of GLUT4

Answer 5

1. Ca2+ released from the SR
2. Insulin binding to its receptor on the plasma membrane

Question 6

What happens when GLUT4 is deleted

Answer 6

A complete attenuation of muscle glucose uptake during contraction/exercise

Question 7

What 3 contraction induced pathways initiate GLUT4 translocation

Answer 7

1. Increased [Ca2+]
2. Increased ATP
3. Epi/NE

Question 8

Calcium induced GLUT4 translocation pathway

Answer 8

Ca2+ –> CAMKK –>CAMK–> GLUT4 (translocate to plasma membrane)

Question 9

Epi/NE pathway

Answer 9

Epi/NE –>Beta adrenergic receptors–> AC–>cAMP–> PKA

Question 10

ATP pathway

Answer 10

ATP –> ADP –> increased [AMP] –> AMPK –> GLUT4 translocation to membrane