Electron Transport Chain Flashcards
Where do the complex’s 1-5 exist in the mitochondria?
Inner Mitochondrial Membrane.
What additional 2 molecules are embedded within the Inner Mitochondrial Membrane alongside complex 1-5?
CoQ & CytC
Complex 1-4 of oxidative phosphorylation is known as what?
Electron Transport Chain
The ATP Synthase (step 5 of oxidative phosphorylation) pumps ______ _______ to generate what?
pumps the “proton gradient” to generate ATP.
What key component of oxidative phosphorylation exists in the mitochondrial matrix?
Protons (Hydrogen Ion)
As NADH approaches Complex I, what conversion occurs?
Gives up it’s proton to become NAD+ and donates its electron to Complex I.
What happens to Complex I when it receives an electron from NADH?
Becomes Supercharged and has the energy to pump protons from the Mitochondrial Matrix into the Intermembrane Space
When complex I becomes supercharged what net effect happens to protons located in the Mitochondrial Matrix.
Complex I pumps protons through the Inner Mitochondrial Membrane to accumulate on the other side in the Intermembrane Space.
What happens to Complex I when a proton gradient is formed in the Intermembrane Space?
Complex I passes it’s electrons to CoQ.
NADH only works at which complex?
Complex I
FADH2 only works at which complex?
Complex II.
FADH2 interacts with which complex and becomes what?
Donates electrons to Complex II to become FAD.
Complex II sends its electrons where?
CoQ
CoQ is the common electron receptor to which 2 complex’s of the electron transport chain?
Complex I & II.
When CoQ donates it’s electrons to Complex III, what happens?
Complex III becomes supercharged and pumps protons from the Mitochondrial Matrix into the Intermembrane Space (Exact same as Complex I)
Where does Complex III pass it’s electrons on to?
CytC.
When CytC donates its electrons to Complex IV, what happens?
Complex IV becomes supercharged and pumps protons from the Mitochondrial Matrix into the Intermembrane Space (Exact same as Complex I & III)
From complex IV, what is the final electron receptor?
Oxygen
When Oxygen receives electrons from Complex IV, what INITIALLY happens?
Oxygen splits into 2 oxygen ions.
When protons are added to the Oxygen Ions (from Complex IV), what happens?
2 water molecules are created (H20 + H20).
What is the final electron receptor of the electron transport chain?
Oxygen
What is the ultimate goal of Complex’s 1-4?
To form a proton gradient in the Intermembrane Space.
What is the energy input that turns ADP into ATP?
Protons flowing from high concentration in the Intermembrane Space down through ATP Synthase to catalyze ADP into ATP.
What are 5 inhibitors of oxidative phosphorylation?
Rotenone, Antimycin, Cyanide Co, Oligomycin, Uncoupling Agent.
