GLUT/SGLT transporters Flashcards
1
Q
GLUT-1
A
- In many mammalian tissues. (including RBC).
* Glucose uptake
2
Q
GLUT-2
A
- Liver
- Pancreas β cell
- Contraluminal membrane of intestinal cell
- High capacity; low affinity
- Regulating insulin release by pancreas;
- Liver; removes glucose after a meal
3
Q
GLUT-3
A
- In many mammalian tissues, especially BRAIN and KIDNEY.
* Glucose uptake
4
Q
GLUT-4
A
- Skeletal muscle
- Heart
- Adipose tissue
• Insulin-stimulated glucose uptake; helps prevent hyperglycemia through insulin action
5
Q
GLUT-5
A
- Small intestine
* Primarily fructose absorption
6
Q
SGLT 1
A
- Small intestine
- Heart
- Trachea
- Kidney (S3)
- Na
- Glucose
- Galactose
7
Q
SGLT 2
A
• Kidney (S1, S2)
- Na
- Glucose
8
Q
SGLT 3
A
- Small intestine
- Uterus
- Lungs
- Thyroid
- Testes
- Na
- and glucose?
9
Q
SGLT 4
A
- Small intestine
- Kidney
- Liver
- Stomach
- Lung
- Glucose
- Mannose
10
Q
SGLT 5
A
- Kidney
* Unknown (glucose and galactose?)
11
Q
SGLT 6
A
- Spinal cord
- Kidney
- Brain
- Small intestine
- Myoinositol
- Glucose
