Glucose Homeostasis Flashcards
What is the importance of glucose?
- Glucose is an important energy substrate
2. This is particularly true for the central nervous system
What happens if blood glucose concentration falls?
- If the blood glucose concentration falls much below normal levels of 4-5 mmol/L (hypoglycaemia), then cerebral function is increasingly impaired.
- If blood glucose concentration <2 mmol/L, unconsciousness, coma and ultimately death can result.
How is glucose broadly regulated?
- Glucose closely regulated
- Feedback system needed for this regulation
- Persistent hyperglycaemia results in diabetes mellitus
What is the most prevalent type of diabetes?
- T2DM
- T1DM
- MODY
What is the mechanism for glucose regulation?
- Increase in blood glucose
- Increase insulin production
- Decrease blood glucose use
- Then glucagon, cortisol, GH and catecholamines
What type of structure is the pancreases gland?
Retroperitonael structure
What does most of the pancreas generate?
-98% generates exocrine secretions via duct to small intestine (exocrine acinar cells secrete enzyme for digestion)
What does the other 2% of the pancreas secrete?
- Small clumps of cells within pancreatic tissue are islets of langerhans
- For glucose homeostasis
What are the different types of cells in islet of Langerhand and what does each one release?
- Alpha cells: glucagon
- Beta cells: insulin
- Delta cells: somatostatin
What type of communication is between islet cells?
Paracrine communication
What are gap junctions?
Allow small molecules to pass directly between cells
What are tight junctions?
Create small intercellular spaces
What in broad terms do pancreatic hormones do?
- Insulin stimulates growth and development and reduces blood glucose
- Glucagon increases blood glucose
- Somatostatin inhibits both insulin and glucagon (and keeps everything in check)
What it eh reaction to increase in blood glucose
-Physiological changes occur in response
to ↑ plasma glucose concentration
-These are required to ensure glucose
levels do not continue to increase beyond physiological values
1. Increase blood glucose Stimulates Beta cells to produce insulin (some aa and GI also does this and PNS activity)
2. If SNS activity switches off beta via alpha cell receptor off and and minor stimulation by beta cell receptor
What does insulin do?
- Build up of glycogen stores (increase glycogenesis)
- Breakdown of glucose (increase glycolysis)
- Uptake of glucose (increase glucose transport into cells via GLUT4)
- Increase of protein synthesis
- Breakdown of fat (increase lipogenesis and decrease lipolysis)