Gluconeogenisis Flashcards
what tissues rely fully on glucose as their source of energy?
- brain
- nervous system
- RBC
- testes
- embryonic tissue
where is the generation of glucose molecules from non-carbohydrates mostly occur?
In the liver in response to hormonal control
how many bypass reactions are there in gluconeogenis?
4 to sidestep the 3 irreversible reactions of glycolysis
where are the bypass reactions carried out?
in the cytosol and the mitochondria
what is the intermediate formed when returning from pyruvate to PEP?
Oxaloacetate
What reaction is the control for gluconeogenis?
Reaction C - F-1,6-BP TO F-6-P
what is the catalyst for reaction d the hydrolysis of G-6-P to glucose?
Glucose-6-phosphatase
where is th G-6-P hydrolysed to glucose?
In the ER lumen
what pathway produces NADPH for all organisms?
pentose phosphate pathway
what is the product of the pentose phosphate pathway?
Pentoses (5 carbon sugars)
What part of the PP-pathway generates NADPH?
The oxidative, irreversible part
what is produced from the reversible part? of the PP-pathway
3-,4-,5-,6- and 7- carbon sugars
what links the catabolic and anabolic pathways?
NADPH
what is NAD+ used for?
metabolism of dietary sugars in the redox reactions of glycolysis and in citric acid cycle
what is NADP+ used for?
Anabolism to convert simple precursors to fatty acids
