Gluconeogenesis Flashcards
What is gluconeogenesis and its function?
production of glucose from non-carbohydrates
its function is to maintain adequate glucose levels in the blood.
What are the 3 reactions that can overcome the irreversible steps of glycolysis?
- synthesis of phosphoenolpyruvate from pyruvate by 2 step reaction w/ oxaloacetate as intermediate
- synthesis of F6P from F1,6-BiP
- production of glucose from G6P
T or F: Glucose is a primary fuel for almost all organisms?
true
How many reactions and which are irriversible?
10 reactions
- glucose> G6P
- F6P> F1,6BiP
- Pyruvate kinase > pyruvate
T or F: gluconeogenesis occurs in the muscle
false, liver and kidneys
what is the yield of this reaction?
- glucose
- 4 ADP
- 2 GDP
- 6 Pi
- 2 NAD
How much ATP and GTP are spent?
4 ATP
2 GTP
when glucose is abundant, _____ is favoured. When glucose is scarce, ____ is favoured.
glycolysis, gluconeogenesis
what are the inhibitors of this process (3)?
- F2,6BiP
- AMP
- ADP
oxaloacetate does not have a transporter in mitchodondria. What is it converted to remedy this?
Malete
T or F: carboxylation can occur w/out Acetyl CoA?
false
What is the major point of regulation?
F1,6BiP > F6P
How do AMP and F26BiP regulate gluconeogenesis?
Activate phosphofructokinase and inhibit F16BiP = slows down gluconeogenesis
how does citrate regulate gluconeogenesis?
inhibits PFK and simulates F16BiP
how does ATP and alanine regulate gluconeogenesis?
inhibit pyruvate kinase
