GLUCOCORTICOID Flashcards
1
Q
When are glucocorticoids used in ocular disease?
A
- post op inflammation
- anterior uveitis
- corneal graft rejection
2
Q
Which immune cells do glucocorticoids affect?
A
- lymphocytes
- macrophages
- leucocytes
3
Q
What are the ocular side effect of steroid use?
A
- cataract formation
- rise in IOP
- reactivation of viral keratitis
- increased risk of bacterial infection
4
Q
How does glucocorticoids cause a rise in IOP?
A
Increased GAG and water blocks the trabecular meshwork resulting in reduced aqueous outflow
5
Q
Is prednisolone phosphate hydrophilic or hydrophobic?
A
Hydrophilic
6
Q
How does the hydrophilic property of prednisolone phosphate affect absorption in the cornea?
A
It is poorly absorbed
7
Q
Which formulations of glucocorticoids are more readily absorbed by the cornea?
A
-Acetate
