EICOSANOIDS

Question 1

What is an eicosanoid?

Answer 1

A substance that is produced from polyunsaturated fatty acids such as arachidonic acid.

Example of eicosanoid is prostaglandins

Question 2

What are eicosanoids produced from?

Answer 2

Phospholipids in the cell membrane

Question 3

What are the three principal eicosanoids?

Answer 3

1. Prostaglandins
2. Leukotrienes
3. Thromboxane

Question 4

Which enzyme is involved in the production of eicosanoids?

Answer 4

Cyclo-oxygenase

Question 5

Which drugs inhibit the cyclo-oxygenase pathway?

Answer 5

• NSAIDs e.g. indomethacin

- Aspirin

Question 6

Which topical NSAIDs are commonly used in ocular surgery?

Answer 6

• Ibuprofen

- Diclofenac

Question 7

What is the purpose of the use of topical NSAIDs in ocular surgery?

Answer 7

Prevention of peri-operative miosis in cataract surgery

Minimise post operative inflammation

Question 8

What is Prostaglandin I2?

Answer 8

Gastro-protective prostglandin

Question 9

What is Prostaglandin I2?

Answer 9

Gastro-protective prostglandin

Question 10

Which COX enzyme is primarily synthesis Prostaglandin I2 (gastro-protective)?

Answer 10

COX-1

Question 11

Which COX enzyme are NSAIDs most active at?

Answer 11

COX 1 more than COX 2.