Glossery Flashcards
adult neurogenesis
The creation of new neurons in the brain of an adult.
amblyopia
Reduced visual acuity that is not caused by optical or retinal impairments.
Asperger’s syndrome
ometimes called high-functioning autism. A syndrome characterized by difficulties in social cognitive processing; usually accompanied by strong language skills.
autism
A disorder arising during childhood, characterized by social withdrawal and perseverative behavior.
behavioral teratology
The study of impairments in behavior that are produced by embryonic or fetal exposure to toxic substances.
binocular deprivation
Depriving both eyes of form vision, as by sealing the eyelids.
caspases
A family of proteins that regulate cell death (apoptosis).
cell adhesion molecule (CAM)
A protein found on the surface of a cell that guides cell migration and/or axonal pathfinding.
cell death or apoptosis
The developmental process during which “surplus” cells die.
cell differentiation
The developmental stage in which cells acquire distinctive characteristics, such as those of
cell migration
The movement of cells from site of origin to final location.
cell-cell interactions
The general process during development in which one cell affects the differentiation of other, usually neighboring, cells.
chemoattractants
Compounds that attract particular classes of growth cones.
chemorepellents
Compounds that repel particular classes of growth cones.
death gene
A gene that is expressed only when a cell becomes committed to natural cell death (apoptosis).
Diablo
A protein released by mitochondria, in response to high calcium levels, that activates apoptosis.
ectoderm
The outer cellular layer of the developing fetus, giving rise to the skin and the nervous system.
embryo
The earliest stage in a developing animal.
fetus
A developing individual after the embryo stage.
filopodia
Very fine, tubular outgrowths from the growth cone.
fragile X syndrome
A condition that is a frequent cause of inherited intellectual disability; produced by a fragile site on the X chromosome that seems prone to breaking because the DNA there is unstable.
growth cone
The growing tip of an axon or a dendrite.
hypoxia
A transient lack of oxygen.
induction
The process by which one set of cells influences the fate of neighboring cells, usually by secreting a chemical factor that changes gene expression in the target cells.
inhibitors of apoptosis proteins (IAPs)
A family of proteins that inhibit caspases and thereby stave off apoptosis.
lamellipodia
Sheetlike extensions of a growth cone.
monocular deprivation
Depriving one eye of light.
multiple sclerosis
terally, “many scars”; a disorder characterized by widespread degeneration of myelin.
nerve growth factor (NGF)
A substance that markedly affects the growth of neurons in spinal ganglia and in the ganglia of the sympathetic nervous system.
neural groove
n the developing embryo, the groove between the neural folds.
neural tube
An embryonic structure with subdivisions that correspond to the future forebrain, midbrain, and hindbrain.
neurogenesis
The mitotic division of nonneuronal cells to produce neurons.
neurotrophic factor
Also called trophic factor. A target-derived chemical that acts as if it “feeds” certain neurons to help them survive.
neurotrophin
A chemical that prevents neurons from dying.
notochord
A midline structure arising early in the embryonic development of vertebrates.
ocular dominance histogram
A graph that portrays the strength of response of a brain neuron to stimuli presented to either the left eye or the right eye.
perseverate
To continue to show a behavior repeatedly
phenylketonuria (PKU)
An inherited disorder of protein metabolism in which the absence of an enzyme leads to a toxic buildup of certain compounds, causing intellectual disability.
process outgrowth
The extensive growth of axons and dendrites.
radial glial cells
Glial cells that form early in development, spanning the width of the emerging cerebral hemispheres, and guide migrating neurons.
regulation
An adaptive response to early injury, as when developing individuals compensate for missing or injured cells.
retrograde degeneration
Destruction of the nerve cell body following injury to its axon.
senile dementia
A neurological disorder of the aged that is characterized by progressive behavioral deterioration, including personality change and profound intellectual decline. It includes, but is not limited to, Alzheimer’s disease.
stem cellsynapse rearrangement
A cell that is undifferentiated and therefore can take on the fate of any cell that a donor organism can produce.
synapse rearrangement
Also called synaptic remodeling. The loss of some synapses and the development of others; a refinement of synaptic connections that is often seen in development.
synaptogenesis
The establishment of synaptic connections as axons and dendrites grow.
ventricular zone
Also called ependymal layer. A region lining the cerebral ventricles that displays mitosis, providing neurons early in development and glial cells throughout life.
zygote
The fertilized egg.
adaptation
The progressive loss of receptor sensitivity as stimulation is maintained.
adequate stimulus
The type of stimulus for which a given sensory organ is particularly adapted.
analgesia
Absence of or reduction in pain.
anterolateral system or spinothalamic system
A somatosensory system that carries most of the pain information from the body to the brain.
capsaicin
A compound synthesized by various plants to deter predators by mimicking the experience of burning.
central modulation of sensory information
The process in which higher brain centers, such as the cortex and thalamus, suppress some sources of sensory information and amplify others.
cingulate cortex
Also called cingulum. A region of medial cerebral cortex that lies dorsal to the corpus callosum.
coding
The rules by which action potentials in a sensory system reflect a physical stimulus.
congenital insensitivity to pain
The condition of being born without the ability to perceive pain.
dermatome
A strip of skin innervated by a particular spinal root.
dermis
he middle layer of skin, between the epidermis and the hypodermis.
dorsal column system
A somatosensory system that delivers most touch stimuli via the dorsal columns of spinal white matter to the brain.
endogenous opioids
A family of peptide transmitters that have been called the body’s own narcotics. The three kinds are enkephalins, endorphins, and dynorphins.
epidermis
The outermost layer of skin, over the dermis.
free nerve ending
An axon that terminates in the skin without any specialized cell associated with it and that detects pain and/or changes in temperature.
generator potential
A local change in the resting potential of a receptor cell that mediates between the impact of stimuli and the initiation of action potentials.
hypodermis
Also called subcutaneous tissue. The innermost layer of skin, under the dermis.
labeled lines
The concept that each nerve input to the brain reports only a particular type of information.
naloxone
A potent antagonist of opiates that is often administered to people who have taken drug overdoses. It binds to receptors for endogenous opioids.
neuropathic pain
Pain caused by damage to peripheral nerves; often difficult to treat.
nociceptor
A receptor that responds to stimuli that produce tissue damage or pose the threat of damage.
Pacinian corpuscle
A skin receptor cell type that detects vibration.
periaqueductal gray
The neuronal body–rich region of the midbrain surrounding the cerebral aqueduct that connects the third and fourth ventricles; involved in pain perception.
polymodal
Involving several sensory modalities.
primary sensory cortex
For a given sensory modality, the region of cortex that receives most of the information about that modality from the thalamus or, in the case of olfaction, directly from the secondary sensory neurons.
primary somatosensory cortex (S1) or somatosensory 1
The gyrus just posterior to the central sulcus where sensory receptors on the body surface are mapped. Primary cortex for receiving touch and pain information, in the parietal lobe.
range fractionation
A hypothesis of stimulus intensity perception stating that a wide range of intensity values can be encoded by a group of cells, each of which is a specialist for a particular range of stimulus intensities.
receptive field
The stimulus region and features that affect the activity of a cell in a sensory system.
receptor cell
A specialized cell that responds to a particular energy or substance in the internal or external environment, and converts this energy into a change in the electrical potential across its membrane.
Ruffini’s ending
A skin receptor cell type that detects stretching of the skin.
secondary sensory cortex or nonprimary sensory cortex
For a given sensory modality, the cortical regions receiving direct projections from primary sensory cortex for that modality.
secondary somatosensory cortex (S2) or somatosensory 2
The region of cortex that receives direct projections from primary somatosensory cortex.
sensory pathway
The chain of neural connections from sensory receptor cells to the cortex.
sensory receptor organ
An organ (such as the eye or ear) specialized to receive particular stimuli.
sensory transduction
The process in which a receptor cell converts the energy in a stimulus into a change in the electrical potential across its membrane.
somatosensory
Referring to body sensation, particularly touch and pain sensation.
specific nerve energies
The doctrine that the receptors and neural channels for the different senses are independent and operate in their own special ways, and can produce only one particular sensation each.
stimulus
A physical event that triggers a sensory response.
synesthesia
A condition in which stimuli in one modality evoke the involuntary experience of an additional sensation in another modality.
thalamus
The brain regions at the top of the brainstem that trade information with the cortex.
threshold
The stimulus intensity that is just adequate to trigger an action potential at the axon hillock.
tonic receptor
A receptor in which the frequency of action potentials declines slowly or not at all as stimulation is maintained.
transient receptor potential 2 (TRP2)
A receptor, found in some free nerve endings, that opens its channel in response to rising temperatures.
transient receptor potential vanilloid type 1 (TRPV1)
Also called vanilloid receptor 1. A receptor that binds capsaicin to transmit the burning sensation from chili peppers and normally detects sudden increases in temperature.
amplitude
The force sound exerts per unit area, usually measured as dynes per square centimeter.
ampulla
An enlarged region of each semicircular canal that contains the receptor cells (hair cells) of the vestibular system.
amusia
A disorder characterized by the inability to discern tunes accurately.
anosmia
The inability to smell.
auditory brainstem implant (ABI)
A type of auditory prosthesis in which implanted microphones directly stimulate the auditory nuclei of the brainstem rather than the cochlea.
basilar membrane
A membrane in the cochlea that contains the principal structures involved in auditory transduction.
binaural
Pertaining to two ears.
Pertaining to two ears.
A hearing impairment that is related to lesions in auditory pathways or centers, including sites in the brainstem, thalamus, or cortex.
cilium
A hairlike extension.
circumvallate papillae
One of three types of small structures on the tongue, located in the back, that contain taste receptors.
cochlea
A snail-shaped structure in the inner ear that contains the primary receptor cells for hearing.
cochlear amplifier
The mechanism by which the cochlea is physically distorted by outer hair cells in order to “tune” the cochlea to be particularly sensitive to some frequencies more than others.
cochlear implant
An electromechanical device that detects sounds and selectively stimulates nerves in different regions of the cochlea via surgically implanted electrodes.
cochlear nuclei
Brainstem nuclei that receive input from auditory hair cells and send output to the superior olivary complex.
conduction deafness
A hearing impairment that is associated with pathology of the external-ear or middle-ear cavities.
cortical deafness
A hearing impairment that is caused by a fault or defect in the cortex.
dendritic knob
A portion of olfactory receptor cells present in the olfactory epithelium.
duplex theory
A theory that we localize sound by combining information about intensity differences and latency differences between the two ears.