Glomulonephritis Flashcards
what is the triad presentation for nephrotic syndrome
- Heavy proteinuria(>3.5g/24hrs), or uPCR of 300-350 mg/mmol
- Hypoalbuminaemia(<30g/L)
- Oedema
- Often little to no haematuria
what are the investigations for nephrotic syngrom
- FBC
- U&E - creatnine
- serum and urine electropheresis (amyloid + lupus)
- complement levels - C3 and C4
- renal biopsy
what are the treatment for nephrotic syndrome
supportive care
-Control fluid – diuretics, ACEi/ARBs, spironolactone
-statins
-anticoagulation
Describe the genetics of alports syndrome
- mutation in type 4 collagen
- X linked
what are the features of alports syndrome
- progressive CKD
- Haematuria
- proteinuria
- Sensorineural Hearing loss
- can develop nephrotic syndrome
what are the presenting syndrome with nephritis
Haematuria + proteinuria
what conditions commonly cause nephrotic syndrome
Minimal change
membranous nephropathy
focal segmental glomerulosclerosis
Diabetic GN
myeloma
amyloidosis
what are the most common causes of nephritis
immune mediated
* lupus
* Crescentic IgA
* Goodpasture’s disease
* ANCA vasculitis
* post strepcocc infections
describe the patholophysiology of golmeruknephritis
- immunlog
how can glomerulonerphrtitis present
- nephritic syndrome
- nephotic syndrome
- CKD
- Asymptomatic urinary abnormalities
what are the clinical features of ANCA -AAV
- systematic imfammmation
how is ANCA-AAV diagonosed
- Serum ANCA
- Changes in ANCA titre correlate with disease activity **
what is minimal change disease
biopsy has minimal change on ligh microscopy but on electron shows fused podocytes
what is the most common cause of asymtomatic urinary abnormalities
IGA-A
