Glomerulonephritis Flashcards
What is the basic filtering unit of the kidney?
Glomerulus
What term is defined as damage to the major components of the glomerulus (podocyte, GBM, capillary endothelium, mesangium)?
Glomerular disease
What is primary glomerular disease?
Glomerular injury limited to the kidney
What is secondary glomerular disease?
Renal abnormalities result from systemic disease
Focal glomerular disease is considered what?
< 50% of glomeruli involved
In general, hematuria should make you think of nephritic disease or nephrotic disease?
Nephritic disease
In general, proteinuria should make you think of nephritic disease or nephrotic disease?
Nephrotic disease
Glomerular disease limited to the kidney is primary or secondary disease?
Primary
Glomerular disease due to systemic disease is primary or secondary disease?
Secondary
Disease that present in the nephritic spectrum and signify inflammatory process causing renal dysfunction is what?
Glomerulonephritis
Deposition of immune complexes into the glomerulus is etiology for what glomerulonephritis or nephrotic syndrome?
Glomerulonephritis
Dysmorphic RBCs, RBC casts, proteinuria < 3.0 and smokey/cola color urine are sx for what disease?
Nephritic syndrome
Cresenteric formation, systemic sx, RBC casts and proteinuria are concerning for what disease?
Rapidly progressive glomerulonephritis (RPGN)
IgA nephropathy (aka Berger disease) is the most common etiology for what?
Primary glomerular disease Peak incidence 2nd/3rd decades of life Post URI by 1-2 days
Glomerular disease etiology that is more common in peds and onset 1-3 wks post GAS infection is what?
Poststreptococcal GN (PSGN)
What labs do you order for Poststreptococcal GN (PSGN)?
ASO titers
What GN etiology has onset post URI, + IgA containing immune complexes?
IgA vasculitis (HSP)
Tetrad for HSP?
- Palpable purpura 2. Arthralgia 3. Abd pain 4. Renal disease
Glomerular nephritis + pulmonary hemorrhage is concerning for what?
Good pasture syndrome
Good pasture disease has what 3 components?
- GN 2. Pulmonary hemorrhage 3. anti-GBM ab
The presence of what are diagnostic for Anti-GBM disease?
anti-GBM ab
What two GN etiologies are classic for rapid progressive GN?
- Anti-GBM disease 2. Pauci-immune GN
T or F: Lupus nephritis presents on a range of injuries (classes I - VI)?
TRUE
ABN UA +/- increased serum creatine w/ + Anti-ds DNA Abs is diagnostic for what?
Lupus nephritis
What GN etiology has positive serology for ANCA?
Pauci-Immune GN
Upper and lower respiratory sx w/ GN + C-ANCA is what systemic ANCA associated vasculitis?
Granulomatosis w/ polyangitis
Absence of granuloma formation, sparing of the upper respiratory tract and + P-ANCA serology is what systemic ANCA associated vasculitis?
Microscopic polyangitis
Asthma and eosinophilia w/ + P-ANCA serology is what systemic ANCA associated vasculitis?
Eosinophilic granulomatosis w/ polyangitis
On US (or CT) you find cyst w/ benign features. What are you concerned about?
Simple cyst
Autosomal dominant polycystic kidney disease affects PKD1/PKD2 or PKHD1 genes?
PKD1 or PKD2
Is polycystic kidney disease inherited? Reversible or irreversible?
Inherited, irreversible
What imaging is preferred in polycystic kidney disease?
Renal US (after 24 weeks gestation if recessive)
What age ranges does autosomal recessive PDK effect?
Infants and children
Pt present w/ BIL markedly enlarged kidneys and congenital hepatic fibrosis, what are you concerned about?
Autosomal recessive PKD
