glomerulonephritis

Question 1

what is glomerulonephritis?

Answer 1

group of disorders resulting from glomerular damage
can lead to proteinuria +/-haematuria
can lead to AKI or ESRF

Question 2

what is the presentation of glomerulonephritis?

Answer 2

asymptomatic haematuria
nephrotic syndrome
nephritic syndrome

Question 3

what are the causes of glomerulonephritis?

Answer 3

idiopathic
immune- SLE, goodpastures, vasculitis
infection- HBV, HCV, strep, HIV
drugs- penicillamine, gold
amyloid

Question 4

what investigations are needed for glomerulonephritis?

Answer 4

blood
- FBC, UE, ESR
- complement C3 +C4
- antibodies- ANA, dsDNA, ANCA, GBM
- serum protein electrophoresis and immunoglobulins
- infection- ASOT, HBC + HCV serology

urine
- urine dipstick- proteinuria +/- haematuria
- spot PCR, MCS
- bence-jones protein

imaging
- CXR- infiltrates in wegeners, goodpastures
- renal US +/- biopsy

Question 5

what is the general management of glomerulonephritis?

Answer 5

refer to renal
rx HTN aggressively <130.80
ACEi/ARA