Glomerulonephritis Flashcards
damage to what cells can lead to vasculitis
mesangium
endothelial cells
damage to podocyte leads to what
non-proliferative lesions and protein in urine
damage to endothelium leads to what
proliferative lesions and red cells in urine
presentation of GN
haematuria AKI/CKD HTN Nephtotic or nephritic syndrome proteinuria
presentation of nephrotic syndrome
proteinuria >3g hypoalbuminaemia fluid retention and oedema hypercholesterolaemia renal vein thrombosis pulmonary emboli volume depletion vitamin D deficiency subclinical hypothyroidism
presentation of nephritic syndrome
AKI oliguria oedema/fluid retention HTN active urinary sediment
classification of proteinuria
microalbuminuria
asymptomatic proteinuria
heacy proteinuria -3g
nephrotic syndrome >3g
non-immunosuppressive management GN
antihypertensives <130/80 ACEI/ARB diuretics statins anticoag/aspirin/antiplatelet fish oil
immunosuppressive management GN
pred azathioprine cyclophosphamide cyclosporin mycophenolate plasmapharesis IV Ig Monoclonal Ab
general management of nephrotic syndrome
fluid and salt restriction ACEI/ARB antiagulate IV albumin if volume depletion diuresis
what is complete remission from nephrotic syndrome regarded as
<300mg protein/day
what is partial remission from nephrotic syndrome regarded as
<3g/day protein
what is minimal change GN, who is it more common in, how is it managed
injury to podocyte and effacement of foot process
children
respond to steroids
what is FSGS and what causes it
focal segmental glomerulosclerosis
HIV, heroin, obesity, reflux nephropathy
how is FSGS managed
steroids, some have chronic disease
