Glomerular Disease Flashcards
too many mesnagial and endothelial cells, immune complex deposition
intrinsic hypercellularity
crescents, rupture of GBM
extrinsic hypercellularity
result of endothelial injury, immune complexes, new BM
double contours
DM and HTN, anitbody or immune complexes
mesangial matrix accumulation
capillary, mesnagial, or linear pattern
immune complex deposition
caused by lupus, HTN, DIC
thrombosis
hematuria, HTN, increased serum creatinine
nephritic syndrome
proteinuria, edema, hyperlipidemia, hypoalbuminemia
nephrotic syndrome
diffuse crescents, common immune injury, nephritic syndrome usually
RPGN
BM thickening, Kimmelsteil-Wilson nodules (hyaline, acellular), commonly with HTN
diabetic nephropathy
thickening of vessel intima
chronic hypertensive glomerulopathy
nephrotic syndrome, global thickening of capillary loops, in situ immune complexes, IgG in capillary pattern, secondary to drugs, infections, neoplasms
membranous glomerulopathy
nephritic/nephrotic syndrome, renal failure, full house inclusion bodies, DNA/RNA antigens
Lupus
recurrent hematuria with upper respiratory infection, mesangial expansion
IgA nephropathy
diffuse lobar hypercellularity, abnormal complement, double contours, hep-C
membranoproliferative glomerulonephritis