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Farmacología de la Diabetes > Glibenclamida > Flashcards

Glibenclamida Flashcards

1
Q

Grupo farmacológico

A

Sulfonilureas

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2
Q

Mecanismo de acción

A

Estimula la liberación de insulina por la célula Beta pancreática al:
Inhibir el receptor SUR1 del canal de K+ dependiente de ATP.
Favoreciendo la despolarización de la célula, permitiendo entrada de Ca2+, generando la exocitosis de la insulina

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3
Q

Farmacocinética relevante

A

Vía: Oral
UPP: >90%
M: Hepático
E: renal (60%) y biliar (40%)

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4
Q

Ventaja

A

PREVIENE DE COMPLICACIONES MICROVASCULARES

Disminuye colesterol total

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5
Q

Expectativa de descenso de HbA1c

A

1 - 2%

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6
Q

Reacciones adversas

A
  • Aumento de peso
  • Hipoglucemia (++)
  • Aplasia medular
  • Eritema nodoso
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7
Q

Contraindicaciones

A
  • Insuficiencia renal
  • Embarazo
  • Lactancia
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8
Q

Indicaciones

A

Diabetes Mellitus tipo 2

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Farmacología de la Diabetes (7 decks)

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