Glaucoma progression analysis

Question 1

What are 2 types of analyses that allow quantitative (rather than subjective) assessment of progression in a visual field series (i.e. assess for progression of glaucoma for a pt over time)?

Answer 1

1. Trend analysis
2. Event analysis

Question 2

What 2 things are measured by trend analysis in glaucoma progression analysis?

Answer 2

1. rate of change of VF
2. statistical significance

Question 3

What are 2 ways taht the measures from trend analysis can be achieved?

Answer 3

1. point by point (point-wise linear regression)
2. on a cluster basis

Question 4

What are 2 examples of trend analysis software for glaucoma progression analysis?

Answer 4

1. PROGRESSOR software
2. PeriData

Question 5

What is meant by event analysis in glaucoma progression analysis?

Answer 5

designed to highlight any VF changes from baseline that are larger than typical clinical variability

Question 6

What are 2 examples of event analysis software?

Answer 6

1. Glaucoma Progression Analysis
2. Humphrey Field Analyser

Question 7

What does glaucoma progression analysis correct for?

Answer 7

media opacities e.g. progressive cataracts that cause a generalised depression

Question 8

What criteria does glaucoma progresison analysis define visual progression according to?

Answer 8

the Early Manifest Glaucoma Trial (EMGT) criteria

Question 9

What is the EMGT criteria for visual progression?

Answer 9

any patient who loses three or more test points in the same location on three consecutive field tests

Question 10

What is calculated by glaucoma progression analysis?

Answer 10

can calculate variability, then adjusts for this to calculate the probability that a change at a specific point is indeed true change or not

Question 11

What do open triangles indicate in the probability plot progression symbol key for glaucoma progression analysis?

Answer 11

when a point is statistically significant from baseline fields at that location

Question 12

What do half-black triangles indicate in the probability plot progression symbol key for glaucoma progression analysis?

Answer 12

if a point has changed on two consecutive fields (indicates possible progression)

Question 13

What do black triangles indicate in the probability plot progression symbol key for glaucoma progression analysis?

Answer 13

if three consecutive fields show change at that particular location (indicates likely progression)

Question 14

What do three half-black triangles in one analysis for glaucoma progression indicate?

Answer 14

possible progression

Question 15

What do three black triangles in one analysis for glaucoma progression indicate?

Answer 15

likely progression

Question 16

At what point can full-threshold strategy fields be used for glaucoma progression analysis?

Answer 16

only as baseline and not as follow up tests

Question 17

What type of VF testing can be used for glaucoma progression analysis follow-up tests?

Answer 17

SITA (standard or fast)