Glaucoma

Question 1

• Congenital glaucoma genes

Answer 1

CYP1B1, GLC3A, GLC3B, GLC3C

Question 2

• Axenfeld rieger genes

Answer 2

Pitx2 or FoxC1

Question 3

• Juvenile onset glaucoma genes

Answer 3

GLC1A (aka MYOC)

Question 4

• Pseudoexfoliation gene

Answer 4

LOXL1

Question 5

• Normal tension glaucoma gene

Answer 5

OPTN

Question 6

• CIGTS

Answer 6

(collaborative initial glaucoma treatment study): med vs trab with similar outcomes after 9 years. If worse baseline fields, trab is better.

Question 7

• Betaxolol:

Answer 7

better for COPD/asthma.

Question 8

• Fuch’s heterocromic iridocyclitis:

Answer 8

chronic low grade inflammation, unilateral. Hard to eradicate inflammation completely. Iris atrophy (diffuse); small stellate KP, early cataract, elevated IOP, absent/minimal synechia, chorioretinal scarring, retinal periphlebitis. Histology shwos plasma cells, macrophages, lymphocytes in iris and ciliary body. Possible association with toxoplasma, CMV, HSV, rubella.