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GIT > GIT Regulatory Substances > Flashcards

GIT Regulatory Substances Flashcards

1
Q

Gastrin is secreted by

A

G cells (antrum of stomach, duodenum)

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2
Q

Gastric motility is increased by

A

Gastrin

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3
Q

Gastrin is inhibited by

A

pH <1.5

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4
Q

Somatostatin inhibited and stimulated by

A

Vagal stimulation

Acid

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5
Q

Pancreatic exocrine cells;
____ cells secrete enzymes by action of _________

____ cells secrete HCO3 by action of _________

A

Acinar, CCK

Ductal, Secretin

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6
Q

Gastric emptying is inhibited by:

A

CCK

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7
Q

Effect of CCK on bile secretion

A

No effect

CCK ↑ gallbladder contraction

secretin ↑ bile secretion

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8
Q

Secretin in secreted by _____ and stimulated by ______

A

S cells.

acid, fatty acid in duodenum lumen

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9
Q

CCK acts on _______ pathways to cause pancreatic secretion

A

neural muscarinic

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10
Q

Full form of GIP according to function.

A

Glucosedependent insulinotropic peptide

Also called gastric inhibitory peptide (GIP)

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11
Q

Vasoactive intestinal polypeptide secreted by______

A

Parasympathetic ganglia in sphincters, gallbladder, small intestine

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12
Q

Vasoactive intestinal polypeptide stimulated by _____ and inhibited by ______

A

by distention and vagal stimulation

by adrenergic input

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13
Q

GIP is secreted by ____

A

K cells in duodenum and jejunum

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14
Q

Enzymes secreted in duodenum and jejunum

A

CCK
Secretin
GIP

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15
Q

Enzymes secreted throughout GI tract

A

Motilin
VIP
Somatostatin

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16
Q

Intrinsic factor

A

Parietal cells (stomach : body and fundus)

17
Q

Gastric acid secretion is inhibited by

A

GPSS

GIP, prostaglandins, secretin, somatostatin

18
Q

Bicarbonates are Trapped in

A

mucus that covers the gastric epithelium

19
Q

Pepsin is stimulated by

A

by vagal stimulation (ACh), local acid

20
Q

After gastrectomy most important supplimentation is

A

Vit B12

21
Q

Gastrojejunostomy results in _____ deficiency

A

Iron

iron deficiency anemia

22
Q

Neuropeptide YY is secreted by _______ and binds to _______

A

ileum and colon

ECL cells

23
Q

Premature activation of trypsinogen is inhibited by

Its defect results in

A
  1. trypsin cleavage by trypsin itself
  2. trypsin inhibitor (SPINK-1)

Hereditary pancreatitis

GIT (5 decks)

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