GIT Regulatory Substances

Question 1

Gastrin is secreted by

Answer 1

G cells (antrum of stomach, duodenum)

Question 2

Gastric motility is increased by

Answer 2

Gastrin

Question 3

Gastrin is inhibited by

Answer 3

pH <1.5

Question 4

Somatostatin inhibited and stimulated by

Answer 4

Vagal stimulation

Acid

Question 5

Pancreatic exocrine cells;
____ cells secrete enzymes by action of _________

____ cells secrete HCO3 by action of _________

Answer 5

Acinar, CCK

Ductal, Secretin

Question 6

Gastric emptying is inhibited by:

Answer 6

CCK

Question 7

Effect of CCK on bile secretion

Answer 7

No effect

CCK ↑ gallbladder contraction

secretin ↑ bile secretion

Question 8

Secretin in secreted by _____ and stimulated by ______

Answer 8

S cells.

acid, fatty acid in duodenum lumen

Question 9

CCK acts on _______ pathways to cause pancreatic secretion

Answer 9

neural muscarinic

Question 10

Full form of GIP according to function.

Answer 10

Glucosedependent insulinotropic peptide

Also called gastric inhibitory peptide (GIP)

Question 11

Vasoactive intestinal polypeptide secreted by______

Answer 11

Parasympathetic ganglia in sphincters, gallbladder, small intestine

Question 12

Vasoactive intestinal polypeptide stimulated by _____ and inhibited by ______

Answer 12

by distention and vagal stimulation

by adrenergic input

Question 13

GIP is secreted by ____

Answer 13

K cells in duodenum and jejunum

Question 14

Enzymes secreted in duodenum and jejunum

Answer 14

CCK
Secretin
GIP

Question 15

Enzymes secreted throughout GI tract

Answer 15

Motilin
VIP
Somatostatin

Question 16

Intrinsic factor

Answer 16

Parietal cells (stomach : body and fundus)

Question 17

Gastric acid secretion is inhibited by

Answer 17

GPSS

GIP, prostaglandins, secretin, somatostatin

Question 18

Bicarbonates are Trapped in

Answer 18

mucus that covers the gastric epithelium

Question 19

Pepsin is stimulated by

Answer 19

by vagal stimulation (ACh), local acid

Question 20

After gastrectomy most important supplimentation is

Answer 20

Vit B12

Question 21

Gastrojejunostomy results in _____ deficiency

Answer 21

Iron

iron deficiency anemia

Question 22

Neuropeptide YY is secreted by _______ and binds to _______

Answer 22

ileum and colon

ECL cells

Question 23

Premature activation of trypsinogen is inhibited by

Its defect results in

Answer 23

1. trypsin cleavage by trypsin itself
2. trypsin inhibitor (SPINK-1)

Hereditary pancreatitis