GIT- Laxatives

Question 1

Stool surfactant that lubricate stool for ease passage

Answer 1

Docusate, mineral oil

Question 2

laxative that activate type 2 chloride channel in SI

Answer 2

Lubiprostone

Question 3

Stimulate guanylase cyclase channel thus causing increase in cGMP & stimulating CFTR

Answer 3

Linaclotide & Blecanatide

Question 4

Inhibit CFTR; treatment of HIV-drug induced diarrhea

Answer 4

Crofelemer

Question 5

widely used stimulant laxative; useful in treating opioid-induced constipation

Answer 5

Senna

Question 6

Available as suppositories and enteric coated tablet that is a potent stimulant of colon

Answer 6

Bisacodyl

Question 7

Bisacodyl side effect

Answer 7

Stomach cramping

Question 8

Laxative that should be avoided by pregnant patient as it may stimulate uterine contractions

Answer 8

Castor oil

Question 9

Laxative that usually causes excavation w/in 4-6 h

Answer 9

Non absorbable sugar or salts (Magnesium hydroxide)

Question 10

MOA of Magnesium hydroxide

Answer 10

osmotic agents increase water content of stool

Question 11

Laxative that increase volume of colon content; stimulate evacuation

Answer 11

Bulk-forming laxatives (Methylcellulose, Psyllium, Polycarbophil)

Question 12

found in lavage solutions; used for complete colonic cleansing before GI endoscopic procedure

Answer 12

Polyethylene Glycol (PEG)

Question 13

Nonabsorbable salts that hold water in intestine by osmosis; distends bowel, increasing intestinal activity, producing defecation in few hours

Answer 13

Saline cathartics (Magnesium citrate & magnesium hydroxide)

Question 14

semisynthetic disaccharide sugar that acts as osmotic laxative; not hydrolyzed by GI enzymes; also used for tx of hepatic encephalopathy

Answer 14

Lactulose