GIT- Acid Peptic Disease, Upper GI Motility, Antidiarrheal

Question 1

Antacid that has a strong laxative effect; can caused osmotic diarrhea

Answer 1

Magnesium hydroxide

Question 2

Has a constipating action; can cause constipation

Answer 2

Aluminum hydroxide

Question 3

Antacid that are absorbed un the gut; have systemic effect

Answer 3

Sodium bicarbonate & Calcium carbonate

Question 4

Can cause metabolic alkalosis in high doses in px. w/ renal insufficiency

Answer 4

Sodium bicarbonate

Question 5

Can cause belching and metabolic alkalosis

Answer 5

Calcium carbonate

Question 6

Suppress basal & meal stimulated acid secretion in linear, dose dependent

Answer 6

H2 receptor Antagonists

Question 7

What are H2 receptor Antagonists

Answer 7

Penitidine, Cimetidine, Farotidine, Nizatidine

Question 8

An H2 receptor antagonist that is a potent CYP enzyme inhibitor

Answer 8

Cimetidine

Question 9

Adverse toxicities of H2 receptor antagonist

Answer 9

musocomial pneumonia, mental status change

Question 10

A mucosal protective agent that is binds to a + charge protein in base of ulcers; forming physical barrier

Answer 10

Sucrolfate

Question 11

A methyl analog of PGE1 that inhibits gastric acid secretion

Answer 11

Misoprostol

Question 12

Toxicity of Sucrolfate

Answer 12

Constipation d/t aluminum salt

Question 13

Toxicities of Misoprostol

Answer 13

GI upset & diarrhea

Question 14

protective coating formation, antimicrobial, enterotoxin sequestration

Answer 14

Bismuth

Question 15

Adverse effect of Bismuth

Answer 15

blackening of stool & tongue

Question 16

What are PPIs

Answer 16

Omeprazole, Esomeprazole, Pantaprazole, Lansoprazole

Question 17

MOA of PPIs

Answer 17

irreversible blockade of H+/K+-ATPase pump

Question 18

Can cause increase risk of bone fracture

Answer 18

PPI

Question 19

Drug interaction of PPI

Answer 19

reduction of stomach acid may reduce absorption of some drugs & increase others

Question 20

Drugs that can induce uterine contraction and thus cause abortifacient

Answer 20

Misoprostol

Question 21

Drug that can cause discoloration of tongue

Answer 21

Bismuth subsalicylate

Question 22

Cimetidine common side effect

Answer 22

Gynecomastia in MEN; Galactorrhea in WOMEN; Estrogenic effect

Question 23

Used in GERD

Answer 23

PPIs- Esomeprazole

Question 24

A D2 receptor blocker ; removes inhibiton of Ach in ENS

Answer 24

Metoclopramide

Question 25

Treatment for patient with delayed gastric emptying

Answer 25

Metoclopramide

Question 26

Toxicities of Metoclopramide

Answer 26

nausea, vomiting, gastroporesis, parkinsonian sx.

Question 27

A D2 receptor blocker same as metoclopramide but has less CNS effect on its toxicities

Answer 27

Domperidone

Question 28

enhance release of Ach at myenteric plexus; decreasing LES pressure & LE peristalsis

Answer 28

Serotonin Receptor Agonists

Question 29

Activates u-opioid receptors in ENS

Answer 29

Loperamide

Question 30

DOC for nonspecific, noninfectious diarrhea

Answer 30

Loperamide

Question 31

Similar to loperamide but high dose can cause CNS opioid effects & toxicity

Answer 31

Diphenoloxylate