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PHARMACOLOGY > GIT- Acid Peptic Disease, Upper GI Motility, Antidiarrheal > Flashcards

GIT- Acid Peptic Disease, Upper GI Motility, Antidiarrheal Flashcards

1
Q

Antacid that has a strong laxative effect; can caused osmotic diarrhea

A

Magnesium hydroxide

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2
Q

Has a constipating action; can cause constipation

A

Aluminum hydroxide

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3
Q

Antacid that are absorbed un the gut; have systemic effect

A

Sodium bicarbonate & Calcium carbonate

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4
Q

Can cause metabolic alkalosis in high doses in px. w/ renal insufficiency

A

Sodium bicarbonate

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5
Q

Can cause belching and metabolic alkalosis

A

Calcium carbonate

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6
Q

Suppress basal & meal stimulated acid secretion in linear, dose dependent

A

H2 receptor Antagonists

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7
Q

What are H2 receptor Antagonists

A

Penitidine, Cimetidine, Farotidine, Nizatidine

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8
Q

An H2 receptor antagonist that is a potent CYP enzyme inhibitor

A

Cimetidine

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9
Q

Adverse toxicities of H2 receptor antagonist

A

musocomial pneumonia, mental status change

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10
Q

A mucosal protective agent that is binds to a + charge protein in base of ulcers; forming physical barrier

A

Sucrolfate

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11
Q

A methyl analog of PGE1 that inhibits gastric acid secretion

A

Misoprostol

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12
Q

Toxicity of Sucrolfate

A

Constipation d/t aluminum salt

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13
Q

Toxicities of Misoprostol

A

GI upset & diarrhea

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14
Q

protective coating formation, antimicrobial, enterotoxin sequestration

A

Bismuth

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15
Q

Adverse effect of Bismuth

A

blackening of stool & tongue

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16
Q

What are PPIs

A

Omeprazole, Esomeprazole, Pantaprazole, Lansoprazole

17
Q

MOA of PPIs

A

irreversible blockade of H+/K+-ATPase pump

18
Q

Can cause increase risk of bone fracture

A

PPI

19
Q

Drug interaction of PPI

A

reduction of stomach acid may reduce absorption of some drugs & increase others

20
Q

Drugs that can induce uterine contraction and thus cause abortifacient

A

Misoprostol

21
Q

Drug that can cause discoloration of tongue

A

Bismuth subsalicylate

22
Q

Cimetidine common side effect

A

Gynecomastia in MEN; Galactorrhea in WOMEN; Estrogenic effect

23
Q

Used in GERD

A

PPIs- Esomeprazole

24
Q

A D2 receptor blocker ; removes inhibiton of Ach in ENS

A

Metoclopramide

25
Q

Treatment for patient with delayed gastric emptying

A

Metoclopramide

26
Q

Toxicities of Metoclopramide

A

nausea, vomiting, gastroporesis, parkinsonian sx.

27
Q

A D2 receptor blocker same as metoclopramide but has less CNS effect on its toxicities

A

Domperidone

28
Q

enhance release of Ach at myenteric plexus; decreasing LES pressure & LE peristalsis

A

Serotonin Receptor Agonists

29
Q

Activates u-opioid receptors in ENS

A

Loperamide

30
Q

DOC for nonspecific, noninfectious diarrhea

A

Loperamide

31
Q

Similar to loperamide but high dose can cause CNS opioid effects & toxicity

A

Diphenoloxylate

PHARMACOLOGY (5 decks)

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