GIT-IBS and IBD

Question 1

5 HT3 SEROTONIN ANTAGONIST that is used for treatment of IBS w/ predominant diarrhea

Answer 1

Alosetron

Question 2

Type 2 chloride channel activator in SI that is used for treatment of IBS w/ predominant constipation in women

Answer 2

Lubiprostone

Question 3

Activates guanylase cyclase that is used for treatment of IBS w/ predominant constipation in adults

Answer 3

Linaclotide

Question 4

topical therapy used in IBD

Answer 4

5-aminosalicylates (Mesalamine)

Question 5

Used in treatment of mild to moderately severe Chron’s disease involving small bowel and ulcerative colitis

Answer 5

Mesalamine

Question 6

MOA of 5-aminosalicylates

Answer 6

inhibition of eicosanoid inflammatory mediators

Question 7

Glucocorticoids that inhibits proinflammatory cytokines has a generalized anti-inflammatory effect used in IBD

Answer 7

Prednisone or Prednisolone

Question 8

Less effective corticosteroid that is metabolized extensively in liver by CYP3A4

Answer 8

Budesonide

Question 9

Antimetabolites that Blocks dihydrofolate reductase

Answer 9

Methatrexate

Question 10

Purine analogs that inhibits synthesis of DNA, RNA, proteins

Answer 10

Azathioprine, 6-Mercaptopurine

Question 11

Treatment for moderately severe to severe Crohn’s disease & ulcerative colitis

Answer 11

Purine analogs & antimetabolites

Question 12

Bind TNF & prevent binding from its receptors

Answer 12

Anti-TNF antibodies (Infliximab)

Question 13

Decrease fat absorption and increase stool fat excretion

Answer 13

Pancreatin

Question 14

dissolves gallstones and reduce hepatic inflammation & fibrosis

Answer 14

Ursodiol

Question 15

Drug used to treat variceal haemorrhage

Answer 15

Octreotide