GIT Colon

Question 1

diagnosis for hirschprung ds

Answer 1

rectal suction biopsy

Question 2

common location of colonic diverticula

Answer 2

sigmoid (vasa recta)

Question 3

complications of diverticcul

Answer 3

hematochezia, diverticulitis (Left sided appendicitis), fistula

Question 4

acquired malformation of mucosal and submucosal capillary beds

Answer 4

angiodysplasia (right side)

Question 5

ischemic damage to the colon usually at the splpenic flexure; postprandial pain; weight loss

Answer 5

ischemic colitis

Question 6

relapsing abdominal pain, improves with defecation, females; dietary fiber can improve

Answer 6

IBS

Question 7

most common type of polyp; left colon; benign; SERRATED on microscopy

Answer 7

hyperplastic polyp

Question 8

Adenomatous polyp vs hyperplastic

Answer 8

premalignant (adenoma Carcinoma sequence)

Question 9

mutation in this gene for RISK of devlt of polyp

Answer 9

APC gene (then KRAS –> p53 –>cox increased)

Question 10

growth of polyps with more risk

Answer 10

sessile growth

Question 11

autosomal dominant disorder wherein apc gene is knocked out

Answer 11

FAP

Question 12

FAP with fibromatosis (retroperitoneum) and osteomas (bone skull)

Answer 12

Gardner syndrome

Question 13

FAP with CNS tumors

Answer 13

Turcot Syndrome

Question 14

hamartomatous polyps thru out the GIT; hyperpigmentation on lips

Answer 14

Peutz Jegher Syndrome

Question 15

second pathway for colorectal CA

Answer 15

microsatellite instability (MSI)

Question 16

Ca that uses MSI

Answer 16

HNPCC