4-2-1 Endocrine Flashcards

0
Q

How do u screen for hyperprolactinemia

A

3 specimens/ 20-30min interval/ average

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1
Q

Responsible for the initiation and maintenance of lactation

A

Prolactin

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2
Q

A female has a prolactin leven of 25.5ug?

A

Hyper!

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3
Q

Prolactin ia highest at people when?

A

Post puberty females

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4
Q

HyperProlac situations 4

A

Pregnancy
Breastfeeding
Prolactinoma
Hypothy

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5
Q

By 3rd trimester what level of PRL

A

500ng

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6
Q

PRL >200; acromegaly

A

Pituitary adenoma

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7
Q

PRL inhibits what hormone?

A

GnRH

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8
Q

Inhibits GH release

A

Somatostatins

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9
Q

Negatively feeds back on pituitary to inhibit gh releas

A

Igf1

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10
Q

Scretory peak of GH

A

20-40ng

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11
Q

Dx of gh deficiency

A

Gh measurement upon pharma stimulation

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12
Q

Meant by: failure of GH suppression after oral glucose load

A

Gh xs

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13
Q

2 causes of GH deficiency

A

Idiopathic

Pituitary adenoma

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14
Q

Gold std for Dx of GHD

A

Insulin tolerance test

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15
Q

Pediatric px GH is measured in ITT as 9ng? Normal or deficient?

A

Deficient
Normal >10ng
Adult >5ng

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16
Q

Second confirmatory test for GHD

A

Arginine combo GHRH test

17
Q

Growth hormone excess manifestation?

A

Acromegaly

Giganstism

18
Q

Screening test for GHxs

A

Random IGF1

19
Q

Posterior pituitary hormone

A

Adh

20
Q

Major function of adh

A

Osmotic homeostasis

21
Q

Suppressed to max secretion

A

284-295mOSM

22
Q

Tantamount to hypoosmolality

A

Hyponat

23
Q

2 types of DI

A

Neuro

Nephrogenic

24
Q

Test choice for dx of di

A

Water deprivation test

25
Q

Administration of additional adh has no effect on water absorption

A

Nephrogenic DI

26
Q

Neurogenic interpretation?

A

Uosm (before test) < posm

Uosm (after test) 50%increase

27
Q

Thyroid hormones

A

TRH
TSH
T3/4

28
Q

3 (unusual sites) where trh is produced

A

Pancreas
Prostate and testis
Myocardium

29
Q

Carries specific info for binding of tsh

A

B subunit

30
Q

Patient has tsh of 0.3?

A

Normal (0.5-5)

31
Q

Steps in thyroxine formation

A
Active teansport
Iodinatiin
Coupling
Lysis
Secretion
Deiodination
32
Q

Thyroid fn tests

A

Tsh
T3 and t4
Others: TRH, t3-up, rT3, TG, TAb

33
Q

Most commonly used tsh assay

A

3rd gen

34
Q

Tsh assay can identify ALL hyper/hypothy except?

A

Hypothalamus and pituitary damage;
Thyroid hormone resistance
Interference of hypothalamus d/t drugs

35
Q

100% from the thyroid gland

A

T4

36
Q

T4 is 15.8?

A

High, 5.5-12.5

37
Q

Laboratory pheochromocytoma measurements

A

Pmet

Plasma catecholamines

38
Q

High prob in PMet when?

A
Normeta = >400
Meta = 236
39
Q

Pharma test for pheochromo

A

Clonidine (suppression)

Glucagon (stimulatory)