GIT biochem Flashcards
location of GLUT
GLUT 1: brain, red cells
GLUT 2: liver, pancreatic B cells
GLUT 4: muscle and adipose tissue
2nd most common cause of hemolytic anemia
pyruvate kinase deficiency
function of glucokinase?
adding phosphate to glucose so cant escape from cell
opposite of glucokinase?
glucose-6-phosphatase
which substrate are used for substrate level phosphorylation?
PEP
BPG
succinyl CoA
3 enzymes dealing with irreversible steps in glycolysis
PFK 1
hexokinase
pyruvate kinase
What does Pyruvate dehydrogenase do
convert pyruvate to acetyl CoA releasing NADH
glucokinase is activated by which hormone
insulin
what is the rate limiting enzyme of glycogen synthesis
glycogen synthase
what is the function of phosphorylase?
use inorganic phosphatase to cleave sugar bond and add phosphatase
rate limiting step for glycogen breakdown?
glycogen phosphorylase
what regulates glycogen phosphorylase
glucagon
epinephrine
AMP
all turns them on
von gierke disease????
enzyme deficiency: glucose-6-phosphatase hypoglycemia hyperurecemia hyperlipidemia fatty liver skin xanthomas
pompe disease?
lysosomal alpha1,4 glycosidase deficiency
cori disease?
glycogen debranching enzyme deficiency
mild liver enlargement
mild hypoglycemia
