GIST Neuroendocrine Tumors

Question 1

Origin of gastrointestinal stromal tumors

Answer 1

Interstitial Cells of Cajal (in the GIT)

Question 2

Gene Mutation involved in GIST

Answer 2

C-Kit (tyrosine kinase), platelet derived growth favtor receptor A

Question 3

Most specific marker for GIST in histology

Answer 3

DOG1

Question 4

Most useful marker for GIST in histology

Answer 4

C-kit (CD117)

Question 5

Treatment of GIST

Answer 5

. Surgical
. Gleevec

Question 6

Name the tumors included in MEN 1 (WERMER syndrome)

What is the genetic mutation?

Answer 6

. Pancreas
. Pituitary adenoma
. Parathyroid

Mutation : MENIN gene AD

Question 7

Name the tumors included in MEN 2 A (SIPPEL’s syndrome)

Gene Mutation?

Answer 7

. Medullary thyroid carcinoma
. Pheochromocytoma
. Parathyroid hyperplasia

Gene Mutation: RET Porto-oncogene (AD)

Question 8

Name the tumors included in MEN 2 B (GORLINE syndome)

Gene mutation?

Answer 8

. Medullary thyroid carcinoma
. Pheochromocytoma
. Marfanoid body habitus
. Multipleucosal neuromata

Gene muattion: RET Porto-oncogene (AD)

Question 9

Treatment of Gastrinoma (Zollinger Ellison syndrome)

Answer 9

PPI
H2 BLOCKERS
SURGICAL

Question 10

. Symptoms of Hypoglycemia
. Low blood glucose
. Symptoms resolved upon correction of Hypoglycemia

This triad is called…….
And is present in which disease?

Answer 10

. Whipple’s triad
. Insulinoma

Question 11

Migratory necrotizing Erythema is present in which disease?

Answer 11

Glucagonoma

Question 12

Glucanoma is called 4D’s syndrome
What are the 4 D’s?

Answer 12

Diabetes
Dermatitis
DVT
Depression