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Microbiology > GI Viruses > Flashcards

GI Viruses Flashcards

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Biology 101 flashcards
1
Q

hep fecal oral

A

A

E

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2
Q

hep blood/sex

A

B
C
D

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3
Q

HBV leading cause of

A

chronic hep
cirrhosis
hepatocellular carcinoma

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4
Q

HBV viral proteins

A 
HBc Ag - capsid antigen
Hbe Ag - variant
HBs Ag - surface antigen (vaccine)
HBV DNA polymerase
HBx protein
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5
Q

primary cause of hepatic cell destruction

A

MHC I –> T cell response to peptides from HBcAG and ABeAg

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6
Q

protective HBV Abs

A

Anti-Hbs

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7
Q

results of acute HBV

A

most: effective cell-mediated and humoral response –> resolution
next: limited immune response –> chronic
least: fulminant

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8
Q

cause of pre-icteric period

A

INF-alpha

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9
Q

Sx of pre-icteric period

A

malaise
anorexia
nausea
RUQ pain

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10
Q

Sx of icteric period

A

jaundice

dark urine

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11
Q

first indicators of HBV

A

HBsAg

HBeAg

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12
Q

indication of chronic infection

A

continued presence of HBsAg > 6 months

absence of anti-HBs

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13
Q

serum markers (resolved)

A

HBeAg: -
HBsAg: -
Anti-HBc: +
Anti-HBs: +

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14
Q

serum markers (chronic)

A

HBeAg: +
HBsAg: +
Anti-HBc: +
Anti-HBs: -

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15
Q

serum markers (vaccinated)

A

HBeAg: -
HBsAg: -
Anti-HBc: -
Anti-HBs: +

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16
Q

asymptomatic carriers (HBV)

A

presence of HBsAg and anti-HBe
little or no viremia
rare hepatitis or liver damage

17
Q

minimal chronic carriers (HBV)

A

higher risk of reactivation

small proportion develop cirrhosis

18
Q

severe chronic hep (HBV)

A

more frequent acute symptoms
progressive liver damage
cirrhosis and hepatocellular carcinoma

19
Q

active HBV immunization

A

HBsAg

20
Q

passive immunization

A

HBIg

21
Q

HDV infection types

A
  1. simultaneous primary coinfection
  2. chronic coinfection (infants born to infected mom)
  3. primary D w/ chronic B
22
Q

polio results

A

95% - asymptomatic
4% - minor illness (abortive)
1% - major (nonparalytic/paralytic)

23
Q

nonparalytic poliomyelitis Sx

A

same as aseptic meningitis

24
Q

rotavirus mechanism

A 
ingestion
infection of epi of jejunum
atrophy of villi
decrease in digestive enzymes
sugars stay in lumen, water follows --> diarrhea
25
Q

rotateq

A

pentavalent vaccine

G1, G2, G3, G4

26
Q

rotarix

A

G1, G3, G4, G9

Microbiology (6 decks)

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