GI tract - Exam 1 Flashcards
UPPER GI bleeding would occur in what 3 places
esophagus, stomach, duodenum
LOWER GI bleeding would occur in what 4 places
jejunum, illiu,m, colon, rectum
signs of UPPER GI bleeding
hematemesis, melena
sign of LOWER GI bleeding
hematochezia
upper GI and lower GI are separated by
the ligament of treitz
dysphagia is
difficulty swallowing
mechanical dysphagia is due to
muscle weakness
functional dysphagia is due to
neuronal issues
an example of rare functional dysphagia
achalasia
achalasia is
denervation of smooth muscle in the esophagus and lower esophageal sphincter
CDAD stands for
c diff associated diarrhea
CDAD occurs bc antiBX…
wipe out normal/beneficial flora and C diff multiplies rapidly
C diff produces ___ and ____
toxins A and B
toxins a and b produce
inflammatory response of diarrhea/colitis & pseudomembranous formation on the lining of the colon by neutrophils
hyper-virrulent strain of c diff
NAP1/207
NAP1/207 has ____ more toxin a and ___ more toxin b
16X more toxin A and 23X more toxin B
____ is a more effective treatment for CDAD than vanco
fecal transplantation (81-94% cured vs 23-31%)
2 types of hiatal hernias
sliding and paraesophageal
sliding hernia is when
stomach comes up through duodenum
paraesophageal hernia is when
stomach comes up and esophageal sphincter goes down through diaphragm
chronic fundal gastritis is also known as
type a
chronic astral gastritis is also known as
type b
chronic fundal gastritis/type a is an ___ reaction
immune
chronic fundal gastritis/type a causes ___ and ____
atrophy and pernicious anemia
chronic antral gastritis/type b is not immune and caused by ___/___
NSAIDS/H pylori
pernicious anemia is ____ anemia
b 12 deficiency
pernicious anemia is usually ___ and caused by a dec in RBC due to B12 deficiency or lack of intrinsic factor
auto-immune
compare erosions and ulcers
erosions are superficial and confined to the epithelial layer vs ulcers which are deep and penetrate into the muscularis mucosa of the duodenal/gastric wall
with a ____ ulcer the pain is IMMEDIATE after eating
gastric
with a ____ ulcer the pain comes 20-30 min after eating
duodenal (chyme empties from stomach to duodenum)
peptic ulcer disease is caused by
helicobacter pylori
h pylori produces ____ which increases gastric inflammation and causes erosions and ulcers
ammonia
____ is associated with gastrinomas
zolling-ellison syndrome
in zolling-ellison syndrome gastrinomas secrete ____ and cause gastric and duodenal ulcers
chronic secretion of gastric acid
____ are peptic ulcers related to a severe illness, multi system organ failure or trauma
stress ulcers
VIT A deficiency will lead to
night blindness
VIT D deficiency will lead to
dec calcium absorption
VIT K deficiency will lead to
clotting issues
VIT E deficiency will lead to (2 things)
testicular atrophy and neurological defects
ulcerative colitis has ____ inflammation of the ____
DIFFUSE inflammation of the mucosal wall (inner)
with UC the inflammation is limited to the
COLON/LI
with UC the pattern of inflammation is
uninterrupted
with chrons disease the inflammation is ____ and ____
patchy and transmural
with CD inflammation affects
ANY part of GI (mouth to anus)
with CD there are ____ and a ____
skip lesions and a cobblestone effect
diverticular disease affects the
COLON/LI
with diverticular disease the asymptomatic stage is ____ and the inflammatory stage is ____
diverticulosis is asymptomatic
diverticulitis is inflammatory
liver cirrhosis is a
irreversible inflammatory fibrotic disease that disrupts liver fx
2 causes of liver cirrhosis
alcohol abuse and viral hepatitis
with liver cirrhosis _______ leading to portal HTN
biliary channels become obstructed
portal HTN is when blood is _____
shunted away from the liver (necrosis)
4 signs/sx of portal HTN
- varices
- distended veins
- ascites
- splenomegaly
varices are caused by ___
portal HTN
varices are distended veins that can occur in the __ (3 places)
esophagus, stomach, rectum
dx tool for ascites
SAAG (serum ascites albumin gradient)
route of transmission for HEP A
fecal/oral route
HEP A is only ___ and is ___
acute and is self-resolving
HEP ___ and ___ have vaccines
A and B
HEP B route of transmission
blood/body fluid, needles, maternal transmission in third tri
HEP C route of transmission
post transfusion, blood, high risk sexual activity
HEP C has no
vaccine
jaundice is also called
icterus
skin pigmentation in jaundice is due to
hyperbilirubinemia
3 causes of jaundice
cirrhosis, hepatitis, hemolysis of RBC
acute pancreatitis dx tool
serum lipase
acute pancreatitis can
resolve spontaneously
chronic pancreatitis is caused by ____ and can lead to ____
alcohol abuse and can lead to chronic changes
with chronic pancreatitis ____ and ____ are destroyed and replaced by scar tissue
acinar cells and islets of langerhans