Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

GI > GI Secretions > Flashcards

GI Secretions Flashcards

0
Q

CFTR

A

on luminal side

activated by cAMP, moves Cl into the lumen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Na/Cl/K transporter

A

On blood side

Moves Na, 2Cl, and K into the epithelial cell to start secretion process of water

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Na/K atpase

A

moves Na out of cell against gradient

maintains the gradients for all of this to work

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What ultimately causes water to enter the lumen

A

Cl in the lumen, Na follows, and then Water will follow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Calcium gated Cl Channel

A

on the luminal side. Ca stimulates Cl influx into the lumen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Control of water into the lumen - CFTR

A

mechanism of control is production of cAMP
PGE2 will bind the E2 receptor, Gs protein, which increases cAMP

MAJOR WAY of controlling secretions.
Get Cl out, Na and H2O will follow.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Control of water into lumen - Ca-Cl channel

A

controlled using NT GALANIN, released from enteric nervous system.
activates Ca Cl channel via Gq protein, increase IP3 and DAG, increase Ca from intracellular stores, channel opens.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Major control of salivation

A

Parasympathetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Serous salivary secretion

A

alpha amylase

K+ and HCO3- higher than plasma. added by duct cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Mucous secreted saliva

A

hypotonic, low Na and Cl, high K and HCO3-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

esophageal secretions

A

mucuous for lubrication and protection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cardiac gland secretion

A

Mucus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Oxyntic Gland secretion

A

mucus
HCL, IF
pepsinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pyloric Glands

A

mucous
gastrin
pepsinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Parietal Cells

A

Acid secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Creation of HCl

A

CO2+H2O with carbonic anhydrase to H2CO3 to H+ and HCO3
want to get the H+ to the lumen
Cl- moves into cell via HCO3/Cl antiport, then moves from cell to lumen
H+ is actiely pumped out of cell H/K atpase

16
Q

Increasing Gastric Acid Secretion

A

Ach and Gastrin bind to parietal cells and causes a small increase
a larger increase happens when they bind to ECFL cells, at M3 receptors and CCKb receptors respectively. Causing the ECFL to produce histamine. which binds to H2 receptor on parietal cell, causing a large increase in HCL secretion

17
Q

How does histamine work to increase HCl secretion

A

Gs coupled receptro increases cAMP

ramps up the H/K atpase

18
Q

Inhibition of gastric acid secretion

A

D cells produce somatostatin= inhibitory
gastrin binds D cells to decrease gastric acid secretion
CCK inhibits gastric acid secretion
PGE2 decreases acid secretion binds Gs, decreases camp, HK never turned on

19
Q

What stimulates pepsinogen secretion

A

secretin
gastrin
Ach
H+

20
Q

Gastric Mucus Barrier

A

mucus secretion triggered by PGE2
forms gel barrier in stomach
asprinin blocks PGE2 (blocking PGE2 affects both the mucosa and the HCl secretion) double whammy

21
Q

Phases of Gastric secretion

A 
Cephalic (increase secretionh, sight, smell thought)
Gastric phase (increase secretion, food in stomach)
Intestinal phase (increase in enzymes, distention of intestine, decrease gastric acid secretion)
22
Q

Pancreatic enzyme secretion

A

(from acinar cells)
Proteolytic (trypsinogen, chymotrypsinogen, procarboxypeptidase)
amylase
lipase (lipase, cholesterol esterase, phospholipase)

enterokinase activates trypsin, trypsin activates the others and self
pancreas also secretes a trypsin inhibitor to prevent autolysis

23
Q

Pancreatic bicarb secretion

A

(made by centroacinar cells in the duct)
these duct cells also secrete water
CO2+H20 in the presence of carbonic anhydrase goes to H2CO3 to HCO3 and H+
HCO3 goes into the lumen via HCO3/Cl exchanger.
goal is to neutralize gastric acids and make an environment that pancreatic and intestinal enzymes can work in

24
Q

Control of pancreatic secretions

A

enzyme secretion - Ach, Gastrin, CCK PZ

bicarb secretion - secretin

25
Q

Phases of pancreatic secretion

A

Cephalic (Ach - increase secretion of ENZYMES)
Gastric (Ach+Gastrin - Enzyme secretion)
Intestinal (CCK and Secretin - increase enzymes and increase bicarb)

26
Q

Hepatic secretions

A

bile salts and bicarb

waste products - bilirubin, cholesterol
bile salts and phospholipids (phospholipids increase solublitity of cholesterol)
water and electrolytes - duct cells and HCO3

27
Q

Control of liver secretions

A

Bile Salts - stimulated by bile salts returning via enterohepatic circulation
water/bicarb - secretin, bile salts (bile salts can be irritating)

28
Q

Role of Gall bladder

A

function - store bile, reabsorb water and electrolytes
Contraction elicited by CCK and vagus
relaxation of sphincter of oddi - CCK pz, and peristalsis

29
Q

Intestinal secretions

A

bicarb and water
mucus
enzymes (memrane of cells as they slough off)

30
Q

Secretions of the colon

A

mucus - tactile stimulation and parasympathetic, for lubrication and to hold feces together and protect from bacteria
bicarb to neutralize acids

GI (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions