GI secretions Flashcards
1
Q
main products of parietal cells
A
- intrinsic factor (cobalamin binding protein) - absorption of B12
- gastric acid
2
Q
what product produced by parietal cells is
○ Stimulated by: Histamine, vagal stimulation, gastrin
○ Inhibited by: Somatostatin, GIP, secretin, prostaglandin
○ Mechanism: H+/K+ ATPase, H+ secreted into lumen
A
gastric acid (HCl)
3
Q
what cells regulate:
● Pepsinogen → Pepsin (main breakdown of protein)
increased by vagal stimulation and acid
A
chief cells
4
Q
mucus (protective barrier that coats the stomach from acid) is secreted by which cells?
A
mucosal cells
5
Q
bicarbonate (which is increased by secretin) can neutralize the acid in the mucosa
is from which cell
A
mucosal cells
6
Q
what cell secretes histamine in order to stimulate gastric acid in parietal cells
A
Enterochromaffin-like Cells (ECL)
