GI Pharmacology III Flashcards
Metoclopramide:
MOA
Uses
Risk/SI
D2 antagonist which increases GI motility (prokinetic)
GERD, impaired gastric emptying, and anti-emetic
Can cause extrapyramidal symptoms
Bethanechol:
MOA
Uses
Risk/SI
M3 agonist (prokinetic)
GERD, gastropareisis
May cause cholinergic side effects
Neostigmine:
MOA
Uses
Risk/SI
AChE Inhibitor (prokinetic) Uses- nonobstructive urinary retention May cause cholinergic side effects
Erythromycin
Motilin receptor agonist (prokinetic)
May cause diarrhea and disrupt gut microbiota
Bulk-forming laxative and possible side effect
MOA
Methylcellulose
May cause gas/bloating from bacteria breaking down fiber
The bulk from the distention produces peristalsis
Surfactant laxative and possible side effect
MAO
Glycerin
May cause nutrient malabsorption
Penetrate the stool by water and lipids to lubricate the stool
Osmotic laxative
Lactulose
Increases the osmotic pressure of the GI tract
Stimulant laxative
Senna
Stimulates the ENS to induce peristalsis
What are the two antidiarrheal opioid agonists?
Loperamide and diphenoxylate
Opioid agonist
Mixes well with red gatorate
MOA
Great for?
Bismuth-subsalicylate
Inhibits PG synthesis and absorbs bacterial toxins
Travelers diarrhea
May get impaired fat absorption with this
MOA
Cholestyramine
Binds bile acids and salts
Used for severe secretory diarrhea and must be given IV
MAO
Octreotide
Activates the somatostatin receptor which increases fluid absorption and decreases motility
What two receptors are in the vestibular system?
H1 and M1 receptors
Anti-emetic: 5HT3 antagonist
Ondansetron, direct
Anti-emetic: M1 antagonist
Scopolamine, direct
