GI Pharmacology II

Question 1

What treats IBS related constipation? What receptor is being utilized? How is the receptor being utilized? Risks?

Answer 1

Tx: Tegaserod
Receptor: 5-HT4
5-HT4 is being stimulated
Risk: Possible MI or stroke

Question 2

What treats IBS related pain and diarrhea? What receptor is being utilized? How is the receptor being utilized? Risks

Answer 2

Tx: Alosetron
Receptor: 5-HT3
5-HT3 is being blocked/antagonized
Risk: ONLY USED IN WOMEN

Question 3

1st line agents for mild to moderate ulcerative colitis (2). Risks?

Answer 3

1. Sulfasalazine
2. Mesalamine
3. Up to 40% of patients may not tolerate these drugs

Question 4

Glucocorticoid drug of choice for treating IBD?

Answer 4

Prednisone

Question 5

Antimetabolites are used for IBD…why? Which population of patients do these drugs work well in?

Answer 5

Antimetabolite medications have immunosuppressive properties that inhibit cell proliferation.
Steroid dependent or steroid unresponsive patients

Question 6

Name all 3 antimetabolite drugs used for IBD

Answer 6

1. 6-mercaptopurine
2. Azathioprine
3. Methotrexate

Question 7

Which drug, that treats IBD, binds and sequesters TNF-a.

Used for what severity of IBD?

Answer 7

Infliximab. Used to treat moderate to severe IBD