GI Pharm Overview

Question 1

Effect of Enkephalin (opioid)

Answer 1

decrease peristalsis via inhibition of Ach and increase secretions
= anti-spasmatic

Question 2

Effect of DA in GI

Answer 2

decrease Ach/inhibits PSNS

–decreases gastric motility,

Question 3

NTs involved in vomitting

Answer 3

DA, Serotonin, Histamine

Question 4

Vomittng center in the brain

Answer 4

area postrema

Question 5

Innvervation controlling salivation

Answer 5

SNS: when stim, increases expulsion of saliva that is low in volume and high in protein (a1) it also contricts vessels in glands (a1 and a2)

PSNS: when stim, increases secretions that are high in volume and low in protein (M3 and M2)
–no PSNS innervation of vessels (they respond to circulatin g Ach and VIP to vasodilate

Question 6

goal of antacids

Answer 6

keep pH > 4 to prevent the conversion of pepsinogen to pepsin

Question 7

Motion stimualtes CN

Answer 7

8

Question 8

Taste stimulates CN

Answer 8

7, 9, 10

Question 9

receptors in the vomiting center/area postrema/chemoreceptor trigger zone

Answer 9

5-HT4, D2, M1, substance P

Question 10

receptors that transmit motion sickenss

Answer 10

M1 and H1