ADEs

Question 1

Cemiveline

Answer 1

contraindicated in glaucoma
SLUDGE BBB, asthma
nephrolithiasis
decrease cognition

Question 2

Pilocarpine

Answer 2

contraindicated in glaucoma
SLUDGE BBB, asthma
nephrolithiasis 
decrease cognition 
PSYCHOSIS

Question 3

Al hydroxide

Answer 3

constipation

Question 4

Mg hydroxide

Answer 4

diarrhea

Question 5

Metoclopramide

Answer 5

Tardative Dyskinesia

= involuntary, repetitive body movements

Question 6

Methylprednisolone

Answer 6

chushings, insulin resistance, glaucoma, osteoporosis, do NOT stop abruptly

Question 7

Sulfasalazine

Answer 7

rash, impotence, anemia

Question 8

laculose

Answer 8

osmotic diarrhea

Question 9

pneumonia

Answer 9

H2 blockers and PPIs

In bedridden pts, the alklinization of the stomach contents promotes bacterial overgrowth which can travel to lungs

Avoided by using sucralfate

Question 10

Abx used to treat H pylori that has high resistnce rate

Answer 10

metronidazole

Question 11

tachyphlaxis

Answer 11

octrotide

Question 12

increases treatment related mortality in NSCLC

Answer 12

Docetaxel

Question 13

ocular toxicities and rarely interstitial lung disease

Answer 13

erlotinib

Question 14

Gemcitabine

Answer 14

peripheral neuropathy

Question 15

Mitomycin

Answer 15

HUS

Question 16

Sunitibib

Answer 16

QT prolongation

Question 17

angioedema

Answer 17

trastuzumab

Question 18

cisplatin

Answer 18

renal and ototoxicity

Question 19

docetaxel

Answer 19

inc NSCLC mortality
edema
contra-liver disese

Question 20

bleeding

Answer 20

bevacizumab and erlotinib

Question 21

CHF

Answer 21

imatinib

Question 22

not effective with KRAS mutation

Answer 22

bevacizumab and cetuximab (KRAS is downstream of where they bind and renders their effect insignificant)

Question 23

Cetuximab

Answer 23

cardiac and/or respiratory arrest and sudden death

Question 24

Metrondiazole

Answer 24

not for pregnancy
metalic taste
peripheral neuropathy

Question 25

C. diff Tx ok to use in pregancy

Answer 25

vancomycin

Question 26

C diff Tx that has limited effect on normal flora

Answer 26

Fidaxomicin

Question 27

birth defects assc with use of metrondiazole during pregnancy

Answer 27

facial anomalies

Question 28

Metamucil

Answer 28

when overused cuases constipation that takes a few days to clear, pts take more and make the probelm worse –> obstruction
**may inhibi coumarin abs

Question 29

Docusate Sodium [Colace]

Answer 29

use only for short period of time bc may irritate mucosa –> abd pain

Question 30

may cuase uterine contractions in a pregnant woman

Answer 30

castor oil

Question 31

Biscodyl [Ducolax]

Answer 31

need enteric coating/should not be crushed up, will cause abd cramps
overuse –> dehydration and electrolyte imbalance

Question 32

antagonizes calmodulin

Answer 32

Loperamide [Imodium] (opiate receptor agonist)

will therefore inhibits contractions

Question 33

anti-emic that is CYP metabolized

Answer 33

aprepitant

Question 34

anti-retroviral that needs to be eaten with fatty food to increase its bio availability

Answer 34

tenofovir, ribavarin, telaprevir, boceprevir

Question 35

anti-retroviral that cannot be taken with food

Answer 35

entacavir (decreases bioavail)

Question 36

Tenofovir

Answer 36

osteoporosis (bone pain and fractures)
RTN (genetic predispostion causes drug to accumulate in tubular epithelial cells)
avoid concurrent use with NSAIDs

Question 37

All HBV drugs are assc with hepato an renal toxicities. why

Answer 37

the drug also inhibits mammalian mitochondrial DNA pol

Question 38

How does hepaotoxicity with HBV anti-retrovirals presents

Answer 38

lactic acidosis and steatosis

Question 39

dose limiting toxicity of interferons

Answer 39

neurophych

Question 40

ribavarin

Answer 40

hemolytic anemia
MI
male teratogenicity and testicular atrophy

Question 41

Telaprefir

Answer 41

RASH (SJS, epidqermal necrolysis)
CYP
binds plasma proteins

Question 42

Boceprevir

Answer 42

CYP

binds plasma proteins