GI Microflora in Health and Disease Flashcards
Which type of immune response (adaptive/innate) is induced in response to the increased gut permeability + bacterial components coming into direct contact with immune cells in IBD?
Adaptive immune response
The combination of which 2 tests have a positive predictive value of 96% and a specificity of 97% for Chron’s disease?
- positive ASCA test (associated w/ Chron)
- negative pANCA test (associated w/ UC)
Refined sugar may be a risk factor for which type of IBD?
Chron Disease, but not UC
Fat intake has been linked to which IBD?
UC
Fermentable fibers are fermented by gut bacteria producing which product important for gut health?
SCFA’s
Which 2 drugs are risk factors for IBD?
- NSAIDS
- OC’s
Which genes found on the IBD-1 locus have defects seen in cases of IBD?
CARD15/NOD2
What is the function of CARD15 found on the IBD-1 locus?
Recognizes and triggers what?
- Intracellular pathogen recognition receptor (PPR)
- Recognizes muramyl dipeptide (MDP) structured molcules
- Triggers activation of NF-kB
CARD15 is primarily expressed on what immune cells?
Monocytes/Macrophages
Normal intestinal microflora may be important in the pathogenesis of__________
Celiac Disease
Pathobionts are microorganisms associated with what conditions?
Chronic inflammatory
Basal activation of which 2 immune cells provide cytokines that maintain integrity of the GI?
- Th17
- Th1