GI Microflora in Health and Disease Flashcards

1
Q

Which type of immune response (adaptive/innate) is induced in response to the increased gut permeability + bacterial components coming into direct contact with immune cells in IBD?

A

Adaptive immune response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The combination of which 2 tests have a positive predictive value of 96% and a specificity of 97% for Chron’s disease?

A
  • positive ASCA test (associated w/ Chron)
  • negative pANCA test (associated w/ UC)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Refined sugar may be a risk factor for which type of IBD?

A

Chron Disease, but not UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Fat intake has been linked to which IBD?

A

UC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Fermentable fibers are fermented by gut bacteria producing which product important for gut health?

A

SCFA’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which 2 drugs are risk factors for IBD?

A
  1. NSAIDS
  2. OC’s
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which genes found on the IBD-1 locus have defects seen in cases of IBD?

A

CARD15/NOD2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the function of CARD15 found on the IBD-1 locus?

Recognizes and triggers what?

A
  • Intracellular pathogen recognition receptor (PPR)
  • Recognizes muramyl dipeptide (MDP) structured molcules
  • Triggers activation of NF-kB
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

CARD15 is primarily expressed on what immune cells?

A

Monocytes/Macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Normal intestinal microflora may be important in the pathogenesis of__________

A

Celiac Disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Pathobionts are microorganisms associated with what conditions?

A

Chronic inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Basal activation of which 2 immune cells provide cytokines that maintain integrity of the GI?

A
  • Th17
  • Th1
How well did you know this?
1
Not at all
2
3
4
5
Perfectly