GI/Liver Flashcards

1
Q

What is the composition of the gut as a muscular tube?

A

Inside:
Lumen
Epithelium
Basement membrane
Lamina proprietary
Muscularis mucosare
Submucosa
Muscular is propria - inner circular layer, outer longitudinal layer
Adventitia (may be lined by serosa (mesophilial cells))
Outside

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2
Q

What is the composition of the gut as a muscular tube?

A

Inside:
Lumen
Epithelium
Basement membrane
Lamina proprietary
Muscularis mucosare
Submucosa
Muscular is propria - inner circular layer, outer longitudinal layer
Adventitia (may be lined by serosa (mesophilial cells))
Outside

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3
Q

What in the gut has a different structure to everything else?

A

The stomach

Lumen
Epithelium
BM
Lamina propria
Muscularis mucosae
Muscularis propria - innermost oblique layer, middle circular layer and the outside longitudinal layer
Submucosa? (Here?)
Adventitia

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4
Q

What is the liver like?

A

Classic lobule
“Area drained by one central hepatic venule”

An artificial construct for understanding hepatic architecture

Roughly hexagonal

It consists of hexagonal plates of hepatocytes stacked on top of each other

Central vein surrounded by portal triad: bile duct, portal vein and hepatic artery (DAV)

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5
Q

What does the liver contain?

A

Portal tract - portal veins, arteries and bile ducts

Hepatocytes arranged in cords with intervening sinusoids

Central veins

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6
Q

What is the acinus?

A

The acinus
Architectural concept based around the blood supply rather than drainage

An artificial construct for understanding hepatic architecture

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7
Q

How do some hepatocytes differ?

A

Some hepatocytes will be more richly oxygenated than others

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8
Q

Acinus vs classic lobule?

A
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9
Q

What are hepatocytes?

A

Principle functional cells of liver
Polyhedral epithelial cells
Abundant mitochondria
Large central spherical nuclei
Prominent nucleoli
May be binucleate

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10
Q

What are teh three important surfaces of the hepatocytes?

A

Sinusoidal (70%)
Permits exchange of material with blood (space of disse)

Canalicular (15%)
Permits excretion of bile

Intracellular (15%)

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11
Q

What do hepatocytes include?

A

Hepatocytes
Large nucleus (>2n)
Prominent nucleolus
Active Golgi apparatus
Prominent endoplasmic reticulum
Lots of mitochondria
Numerous peroxisomes

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12
Q

What are sinusoids like?

A

Sinusoids
Highly specialised blood vessels

Thin discontinuous fenestrated endothelium

No basement membrane

Contains scattered Kupffer cells

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13
Q

What is the interhepatic biliary tree like?

A

Intrahepatic biliary tree
Simple cuboidal-to-columnar epithelium

Canaliculi -> bile ductules -> trabecular ducts -> bile ducts

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14
Q

What are teh functions for the gallbladder?

A

Functions
Concentrates and stores bile

Expels bile via common bile duct into duodenum
Specialised mucosa
Smooth muscle layer

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15
Q

What is in the gallbladder?

A

Gallbladder

Specialised mucosa
Simple columnar epithelium
Microvilli
Thrown into folds
Adapted for water and salt absorption

Connective tissue lamina propria

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16
Q

What si teh function of the exocrine pancreas?

A

To synthesise and secrete enzymes and bicarbonate-rich fluid into the duodenum

Poorly defined fibrous capsule with septa dividing gland into lobules

Epithelial cells arranged in acini

Pancreas.

17
Q

What are acinus cells like?

A

Acinar cells
Epithelial

Pyramidal shape

Basally - rich in RER

Apically - Zymogen granules (enzyme precursors)

18
Q

What are the duct system in the exocrine pancreas’s?

A

Ducts
Centroacinar cells
->
Intercalated ducts
->
Interlobular ducts - cuboidal epithelium
->
Main pancreatic duct - becomes low cuboidal and then columnar epithelium here

19
Q

What are the epithelial organs?

A

The liver and pancreas are epithelial organs

20
Q

How are hepatocytes arranged?

A

Hepatocytes arranged in plates around central veins

21
Q

What can describe as lobules or acini?

A

Portal triads of hepatic artery, bile duct and portal vein branches. Can describe as lobules or acini.

22
Q

What does the biliary system do?

A

Biliary system transports and concentrates bile

23
Q

What does the exocrine pancreas comprise?

A

•Exocrine pancreas comprises acini with pyramidal cells and zymogen granules and specialised duct system