GI Infections Flashcards
Suprantigen in GI tract Vomiting, watery non-bloody diarrhoea B haemolytic colonies on blood agar From poor food handling Appears in tetrad clusters G stain
Staph Aureus
Reheated fried rice
Bacillus Cereus
Bacillus Cereus toxins (x2)
Heat stabile (emetic) and Heat labile (diarrhoeal)
Treatment Bacillus Cereus?
None, self limiting
Treatment S Aureus?
None, self limiting
Canned foods, bacteria in honey (infants)
Preformed toxin
Clostridium Botulinum
Preformed toxin, block of ACh release
Descending paralysis
Clostridium Botulinum
Treatment of Clostridium Botulinum
Antitoxin
Reheated meat, superantigen causes systemic toxicity
Vomiting, watery diarrhoea, lasts 24 hours
rapid onset
Clostridium Difficile
Aesculin positive with tumbling motility
Listeria Monocytogenes
Unpasteurized dairy, ‘cold enhancement’
Listeria Monocytogenes
Treatment of Listeria Monocytogenes
Ampicillin (+ ceftriaxone, cotrimoxazole)
E. Coli - ETEC
Enterotoxigenic E. coli
Traveller’s diarrhoea
E. Coli - EPEC
Enteropathogenic E. coli Infantile diarhoea (Paeds)
E. Coli - HUS (3 features)
Anaemia, thrombocytopaenia, renal failure
E. Coli - EIEC
Invasive dystentry
Enteroinvasive E. Coli
E. Coli - EHEC
Haemorrhagic (verotoxin)
Enterohemorrhagic E Coli
Multiplies in Peyer’s patches
Salmonella typhi
Rose spots, slow onset fever, bradycardia
CONSTIPATION
Salmonella typhi
Treatment of E. Coli
Self limiting but can treat with Ciprofloxaxin
Treatment of Salmonella
Ceftrioxone, or ciprofloxacin
Poultry, meat, eggs
non-lactose fermenting
Salmonella enteritidis
Handling reptiles
Salmonella
Fever, pain, bloody diarrhoea
Very low effective dose
Production of enterotoxin
Shigellae
Rice water stool
Vibrio Cholerae
Increased CAMP, efflux of Cl- into lumen
Massive diarrhoea without inflammatory cells
Vibrio Cholerae
Raw seafood, common in Japan
Diarrhoea x3 days
Vibrio Parahaemolyticus
Shellfish handler/diver
Vibrio Vulnifcus
Treatment of Vibrio Parahaemolyticus/Vulnifcus
Doxycycline
Bloody foul smelling stool
Prodrome - fever, abdo pain
Oxidase +ve
Poutry, meat, unpasteruised milk
Campylobacter Jejuni
Treatment of Campylobacter Jejuni
Erythromycin or ciprofloxacin
Mesenteric adenitis with necrotising granulomas
Farm animals
Extra GI symptoms - arthritis, erythema nordosum
Yersinia enterocolitica
Flask shaped ulcer
Entamoeba Histolytica
Motile trophozoite/non motile cyst
4 nuclei
Entamoeba Histolytica
Treatment Entamoeba Histolytica (x2)
Metronidazole + Paramomycin
Pear shaped trophozoite
Giardia lamblia
Travelers, hikers, cruise ships, MSM
Malabsorption of protein and fat - foul smelling non-bloody diarrhoea
Giardia lamblia
String test
2 nuclei
Giardia lamblia
Treatment of Giardia lamblia
Metronidazole
Swimming pools, particularly immunocompromised
Oocysts in stool by Kinyoun Acid Fast Stain
Cryptosporidium parvum
Treatment cryptosporidium parvum
Paromomycin
dsDNA, ‘wheel like’
Watery diarrhoea
Rotavirus